替莫泊芬钠（第二代光敏剂）光动力疗法对口腔鳞状细胞癌的疗效：系列 8 例。
The effect of photodynamic therapy with talaporfin sodium, a second-generation photosensitizer, on oral squamous cell carcinoma: A series of eight cases.
机构信息
Department of Dentistry, Sasebo City General Hospital, 9-3 Hirase-machi, Sasebo, Nagasaki 857-8511 Japan.
Department of Regenerative Oral Surgery, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588 Japan.
出版信息
Photodiagnosis Photodyn Ther. 2018 Mar;21:176-180. doi: 10.1016/j.pdpdt.2017.11.016. Epub 2017 Dec 2.
OBJECTIVE
To assess the effect of photodynamic therapy (PDT) with talaporfin sodium, a second-generation photosensitizer, on oral squamous cell carcinoma (SCC).
METHODS
Eight patients who were diagnosed with oral SCC without any metastasis and underwent talaporfin sodium-mediated PDT (t-PDT) were included in this study. Biopsies were performed 4-6 weeks after t-PDT. The clinical response was evaluated using Response Evaluation Criteria in Solid Tumors.
RESULTS
Complete response (CR) was achieved in six of eight cases, and two cases showed partial response (PR) as a clinical outcome of t-PDT. Recurrence occurred in one of the CR cases 9 months after irradiation. The patient underwent tumor resection and no recurrence was found after surgery. The two cases with PR died from the cancer despite additional PDT.
CONCLUSION
t-PDT is an effective treatment strategy for oral SCC. Talaporfin sodium has an advantage with regard to early elimination from the body compared with porfimer sodium.
目的
评估二氢卟吩 e6（talaporfin sodium）介导的光动力疗法（PDT）对口腔鳞状细胞癌（SCC）的疗效。
方法
本研究纳入了 8 例无转移的口腔 SCC 患者，均接受了二氢卟吩 e6 介导的 PDT（t-PDT）。t-PDT 后 4-6 周进行活检。采用实体瘤反应评价标准（Response Evaluation Criteria in Solid Tumors）评估临床反应。
结果
8 例患者中，6 例达到完全缓解（CR），2 例为部分缓解（PR）。CR 病例中有 1 例在照射后 9 个月复发，该患者接受了肿瘤切除术，术后未发现复发。2 例 PR 患者尽管接受了额外的 PDT，但仍死于癌症。
结论
t-PDT 是口腔 SCC 的有效治疗策略。与血卟啉衍生物相比，二氢卟吩 e6 具有早期从体内清除的优势。
Zotero 插件