Tjessem Ingvild Holm, Al-Far Hanine Fadel Mustafa, Fuglsang Jens, Lauszus Finn Friis
Department of Obstetrics/Gynecology, Herning, Herning Hospital, Gl. Landevej 61, DK-7400 Herning, Denmark.
Department of Obstetrics/Gynecology, Herning, Herning Hospital, Gl. Landevej 61, DK-7400 Herning, Denmark.
Pregnancy Hypertens. 2018 Apr;12:150-154. doi: 10.1016/j.preghy.2017.11.011. Epub 2017 Nov 23.
The objective of this study was to evaluate the association between the ambulatory arterial stiffness index (AASI) and markers of microvascular disease during pregnancy in women with type 1 diabetes.
A total of 151 women with type 1 diabetes mellitus were recruited for repeat 24-h BP recordings thrice during pregnancy and once three months post partum. Fifty women without diabetes served as controls. The AASI and pulse pressure (PP) were computed from blood pressure recordings. Repeated measures analysis of variance was used for comparison between groups during and after pregnancy. Linear regression analysis was performed with AASI and PP as dependent variables and albuminuria and retinopathy as independent variables.
AASI during diabetic pregnancy and association with microvascular disease.
Micro- or macroalbuminuria was present in 23% of the women and 58% had either simplex or proliferative retinopathy. The AASI was inversely associated with the coefficient of determination, which means that the stiffer vascular wall the more random variability in BP.
AASI showed a strong association with microvascular disease during pregnancy in women with type 1 diabetes. Together with the flattened circadian rhythm this indicates a pregnancy-related functional change in the vascular bed.
本研究的目的是评估1型糖尿病女性孕期动态动脉僵硬度指数（AASI）与微血管疾病标志物之间的关联。
共招募了151名1型糖尿病女性，在孕期进行三次24小时血压重复测量，并在产后三个月进行一次测量。50名无糖尿病女性作为对照。根据血压记录计算AASI和脉压（PP）。采用重复测量方差分析对孕期及产后不同组间进行比较。以AASI和PP作为因变量，蛋白尿和视网膜病变作为自变量进行线性回归分析。
糖尿病孕期的AASI及其与微血管疾病的关联。
23%的女性存在微量或大量蛋白尿，58%患有单纯性或增殖性视网膜病变。AASI与决定系数呈负相关，这意味着血管壁越僵硬，血压的随机变异性越大。
1型糖尿病女性孕期AASI与微血管疾病密切相关。连同昼夜节律变平，这表明血管床存在与妊娠相关的功能变化。
