Department of Biomedical Imaging and Image-guided Therapy, Division of General and Pediatric Radiology, Medical University of Vienna, Waehringer Guertel, Vienna, Austria, E.U.
Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Waehringer Guertel, Vienna, Austria, E.U.
PLoS One. 2017 Dec 5;12(12):e0189093. doi: 10.1371/journal.pone.0189093. eCollection 2017.
To investigate whether elevated glucose metabolism in neurofibroma, determined by [F18]-FDG-PET, is correlated with cell density in MRI, as expressed through the apparent diffusion coefficient.
Patients diagnosed with neurofibromatosis type 1 and peripheral nerve sheath tumors (PNST) were enrolled in this prospective, IRB-approved study. After a single [F18]-FDG injection, patients consecutively underwent [F18]-FDG-PET/CT and [F18]-FDG-PET/MRI on the same day. Maximum and mean standardized uptake values (SUVmax, SUVmean) on [F18]-FDG-PET/CT and [F18]-FDG-PET/MRI were compared, and correlated with minimum and mean apparent diffusion coefficients (ADCmean, ADCmin).
A total of 12 (6 male/6 female, mean age was 16.2 ± 5.2 years) patients were prospectively included and analyzed on a per-lesion (n = 39) basis. The SUVmean of examined PNST showed a moderate negative correlation with the ADCmean (r = -.441) and ADCmin (r = -.477), which proved to be statistically significant (p = .005 and p = .002). The SUVmax of the respective lesions, however, showed a weaker negative correlation for ADCmean (r: -.311) and ADCmin (r: -.300) and did not reach statistical significance (p = .054 and p = .057). Lesion-based correlation between [F18]-FDG-PET/MRI and [F18]-FDG-PET/CT showed a moderate correlation for SUVmax (r = .353; p = .027) and a strong one for SUVmean (r = .879; p = .001)). Patient-based liver uptake (SUVmax and mean) of [F18]-FDG-PET/MRI and [F18]-FDG-PET/CT were strongly positively correlated (r = .827; p < .001 and r = .721; p < .001) but differed significantly (p < .001).
We found a statistically significant, negative correlation between glucose metabolism and cell density in PNST. Thus, ADCmean and ADCmin could possibly add complimentary information to the SUVmax and SUVmean and may serve as a potential determinant of malignant transformation of PNST.
通过[F18]-FDG-PET 评估神经纤维瘤中的葡萄糖代谢升高，并研究其与 MRI 中的细胞密度（以表观扩散系数表示）之间的相关性。
本研究为前瞻性、IRB 批准的研究，纳入了诊断为 1 型神经纤维瘤病和周围神经鞘瘤（PNST）的患者。患者在单次[F18]-FDG 注射后，于同一天连续进行[F18]-FDG-PET/CT 和[F18]-FDG-PET/MRI 检查。比较[F18]-FDG-PET/CT 和[F18]-FDG-PET/MRI 上的最大和平均标准化摄取值（SUVmax、SUVmean），并将其与最小和平均表观扩散系数（ADCmean、ADCmin）进行相关性分析。
共有 12 名（6 名男性/6 名女性，平均年龄为 16.2±5.2 岁）患者前瞻性纳入并进行了基于病变的分析（n=39）。检查的 PNST 的 SUVmean 与 ADCmean（r=-0.441）和 ADCmin（r=-0.477）呈中度负相关，相关性具有统计学意义（p=0.005 和 p=0.002）。然而，各自病变的 SUVmax 与 ADCmean（r=-0.311）和 ADCmin（r=-0.300）的负相关性较弱，且无统计学意义（p=0.054 和 p=0.057）。基于病变的[F18]-FDG-PET/MRI 和[F18]-FDG-PET/CT 之间的相关性显示，SUVmax 的相关性为中度（r=0.353；p=0.027），SUVmean 的相关性为高度（r=0.879；p=0.001））。患者的[F18]-FDG-PET/MRI 和[F18]-FDG-PET/CT 的肝脏摄取（SUVmax 和 SUVmean）呈强烈的正相关（r=0.827；p<0.001 和 r=0.721；p<0.001），但差异具有统计学意义（p<0.001）。
我们发现 PNST 中的葡萄糖代谢与细胞密度之间存在统计学显著的负相关。因此，ADCmean 和 ADCmin 可能为 SUVmax 和 SUVmean 提供补充信息，并可能成为 PNST 恶性转化的潜在决定因素。
Zotero 插件
