穿心莲内酯增强了三氧化二砷对肝细胞癌的抗肿瘤作用。
The antitumor effect of arsenic trioxide on hepatocellular carcinoma is enhanced by andrographolide.
作者信息
Duan Xuhua, Li Tengfei, Han Xinwei, Ren Jianzhuang, Chen Pengfei, Li Hao, Gong Shaojun
机构信息
Department of Interventional Radiology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan Province, People's Republic of China.
出版信息
Oncotarget. 2017 Jun 27;8(53):90905-90915. doi: 10.18632/oncotarget.18677. eCollection 2017 Oct 31.
High concentrations of arsenic trioxide (AsO) are used to treat acute promyelocytic leukemia and solid tumors, with negative side effects to normal cells. Andrographolide is a traditional Chinese medicine that exerts anti-cancer, anti-inflammatory, anti-virus, and anti-diabetic effects. Here, we tested the effects of combined andrographolide with AsO against hepatocellular carcinoma (HCC). We found that by increasing apoptosis, andrographolide synergistically enhanced the anti-tumor effects of As2O3 in HepG2 cells and . Furthermore, results from our microarray assays and experiments with mouse xenografts showed that EphB4 was downregulated by the combination of AsO plus andrographolide. These findings suggest that the combination of andrographolide and AsO could yield therapeutic benefits in the treatment of HCC.
高浓度三氧化二砷（AsO）用于治疗急性早幼粒细胞白血病和实体瘤，但对正常细胞有负面副作用。穿心莲内酯是一种具有抗癌、抗炎、抗病毒和抗糖尿病作用的传统中药。在此，我们测试了穿心莲内酯与AsO联合对肝细胞癌（HCC）的影响。我们发现，穿心莲内酯通过增加细胞凋亡，协同增强了As2O3对HepG2细胞的抗肿瘤作用。此外，我们的微阵列分析和小鼠异种移植实验结果表明，AsO与穿心莲内酯联合可下调EphB4。这些发现表明，穿心莲内酯与AsO联合在HCC治疗中可能产生治疗益处。
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