癌胚抗原在小细胞肺癌合并腺癌诊断中的应用价值
Usefulness of carcinoembryonic antigen in the diagnosis of small cell lung cancer combined with adenocarcinoma.
作者信息
Lei Lei, Chen Qixun, Wang Zeng, Han Na, Chen Bo, Qin Jing, Lu Hong-Yang
机构信息
Zhejiang Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology (Lung and Esophagus), Zhejiang Cancer Hospital, China.
Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, China.
出版信息
Adv Clin Exp Med. 2017 Oct;26(7):1091-1094. doi: 10.17219/acem/66372.
BACKGROUND
Small cell lung cancer (SCLC) includes pure SCLC and SCLC combined with other pathologies (C-SCLC). C-SCLC accounts for about 28% of all SCLCs subjected to surgical resection, but only about 1%-3% of C-SCLCs are detected by biopsy. Since less than 5% of SCLC patients are eligible for surgery, it is necessary to develop alternative methods for the detection of C-SCLC.
OBJECTIVES
We determined whether serum carcinoembryonic antigen (CEA) levels, which are usually elevated in lung adenocarcinomas, could be used to differentiate between pure SCLC and SCLC combined with adenocarcinoma.
MATERIAL AND METHODS
We reviewed the records of 41 SCLC patients (35 with pure SCLC, 6 with C-SCLC) who underwent surgical resection between 2000 and 2014 in Zhejiang Cancer Hospital. Their preoperative serum CEA levels were noted, and the relationship between CEA level and the type of SCLC was analyzed.
RESULTS
Serum CEA levels >6ng/mL were found more frequently in C-SCLC patients than in pure SCLC patients (p = 0.031). No such difference was observed when a CEA cut-off of 5ng/mL was used (p = 0.316).
CONCLUSIONS
A preoperative serum CEA of >6ng/mL may be used as a reference in the diagnosis of SCLC combined with adenocarcinoma.
背景
小细胞肺癌（SCLC）包括纯小细胞肺癌和合并其他病理类型的小细胞肺癌（C-SCLC）。C-SCLC约占所有接受手术切除的SCLC的28%，但活检仅能检测出约1%-3%的C-SCLC。由于不到5%的SCLC患者适合手术，因此有必要开发检测C-SCLC的替代方法。
目的
我们确定通常在肺腺癌中升高的血清癌胚抗原（CEA）水平是否可用于区分纯SCLC和合并腺癌的SCLC。
材料与方法
我们回顾了2000年至2014年期间在浙江省肿瘤医院接受手术切除的41例SCLC患者（35例纯SCLC，6例C-SCLC）的记录。记录他们术前的血清CEA水平，并分析CEA水平与SCLC类型之间的关系。
结果
C-SCLC患者血清CEA水平>6ng/mL的情况比纯SCLC患者更常见（p = 0.031）。当使用5ng/mL的CEA临界值时，未观察到这种差异（p = 0.316）。
结论
术前血清CEA>6ng/mL可作为诊断合并腺癌的SCLC的参考。
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