正电子发射断层扫描（PET）与神经退行性疾病研究中的多示踪剂概念
PET and the multitracer concept in the study of neurodegenerative diseases.
作者信息
Engler Henry, Damian Andres, Bentancourt Cecilia
机构信息
MD. PhD - Uruguayan Centre of Molecular Imaging (CUDIM), Montevideo, Uruguay.
MD - Uruguayan Centre of Molecular Imaging (CUDIM), Montevideo, Uruguay.
出版信息
Dement Neuropsychol. 2015 Oct-Dec;9(4):343-349. doi: 10.1590/1980-57642015DN94000343.
The complexity of the pathological reactions of the brain to an aggression caused by an internal or external noxa represents a challenge for molecular imaging. Positron emission tomography (PET) can indicate anatomopathological changes involved in the development of different clinical symptoms in patients with neurodegenerative disorders. PET and the multitracer concept can provide information from different systems in the brain tissue building an image of the whole disease. We present here the combination of F-flourodeoxyglucose (FDG) and N-[C-methyl]-L-deuterodeprenyl (DED), FDG and N-[C-methyl] 2-(4'-methylaminophenyl)-6-hydroxybenzothiazole (PIB), PIB and L-[C]-3'4-Dihydrophenylalanine (DOPA) and finally PIB and [O]H2O.
大脑对由内部或外部有害因素引起的侵害所产生的病理反应的复杂性，对分子成像构成了挑战。正电子发射断层扫描（PET）可以显示神经退行性疾病患者不同临床症状发展过程中涉及的解剖病理学变化。PET和多示踪剂概念可以从脑组织中的不同系统提供信息，构建整个疾病的图像。我们在此展示氟脱氧葡萄糖（FDG）与N-[C-甲基]-L-去氘司来吉兰（DED）、FDG与N-[C-甲基] 2-(4'-甲氨基苯基)-6-羟基苯并噻唑（PIB）、PIB与L-[C]-3'4-二氢苯丙氨酸（DOPA）以及最后PIB与[O]H2O的组合。
Zotero 插件