尼日利亚西南部农村地区乙型肝炎和丁型肝炎病毒合并感染个体的血清β2微球蛋白升高。
Elevated serum β2-microglobulin in individuals coinfected with hepatitis B and hepatitis D virus in a rural settings in Southwest Nigeria.
作者信息
Okoror Lawrence Ehis, Ajayi Ayodele Oluwaseun, Ijalana Oluwaseun Benjamin
机构信息
Department of Microbiology, Federal University, PMB 373, Oye-Ekiti, Ekiti State, Nigeria.
Biosolution Technologies, Olusegun Obasanjo Way, Akure, Nigeria.
出版信息
BMC Res Notes. 2017 Dec 8;10(1):719. doi: 10.1186/s13104-017-3015-9.
OBJECTIVE
Coinfection of hepatitis B virus (HBV) with hepatitis D virus (HDV) has being reported to increase severity of progression to hepatocellular carcinoma (HCC) and liver cirrhosis (LC). Beta microglobulin (2βM) which is present on the surfaces of blood cells in acceptable levels is a tumor marker which may become elevated in disease conditions. This study hence observed the prevalence of HBV and HDV coinfection in a rural population and their 2βM concentration.
RESULTS
Of the 368 samples, 66 (17.9%) were positive to hepatitis B surface antigen (HBsAg) and 33 (50%) were coinfected with HDV, 8 (2.1%) were monoinfected with HDV. 2βM concentration increased beyond the normal level in individuals coinfected with HBV and HDV as compared with the monoinfected individuals. Coinfection resulted in the increased concentration of 2βM in HBV and HDV coinfection and the likelihood of progression to HCC and LC may not be ruled out. Monoinfection with HDV also had high 2βM concentration but this is due to having being infected with a non-detected HBV or chronic infection in which HBV is clearing.
目的
据报道，乙型肝炎病毒（HBV）与丁型肝炎病毒（HDV）合并感染会增加进展为肝细胞癌（HCC）和肝硬化（LC）的严重程度。β微球蛋白（2βM）在血细胞表面以可接受的水平存在，是一种肿瘤标志物，在疾病状态下可能会升高。因此，本研究观察了农村人群中HBV和HDV合并感染的患病率及其2βM浓度。
结果
在368份样本中，66份（17.9%）乙型肝炎表面抗原（HBsAg）呈阳性，33份（50%）合并感染HDV，8份（2.1%）为HDV单感染。与单感染个体相比，HBV和HDV合并感染个体的2βM浓度超过正常水平。合并感染导致HBV和HDV合并感染时2βM浓度升高，且不能排除进展为HCC和LC的可能性。HDV单感染也有较高的2βM浓度，但这是由于感染了未检测到的HBV或HBV正在清除的慢性感染。
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