[与静脉铁剂外渗相关的皮肤色素沉着：来自法国药物警戒数据库的分析]
[Cutaneous pigmentation related to intravenous iron extravasation: Analysis from the French pharmacovigilance database].
作者信息
Hermitte-Gandoliere Alexia, Petitpain Nadine, Lepelley Marion, Thomas Laure, Le Beller Christine, Astoul Jacqueline Ponte, Gillet Pierre
机构信息
Service de pharmacie, hôpital de Mercy, CHR de Metz-Thionville, 57085 Metz, France.
Centre régional de pharmacovigilance de Nancy, CHRU de Nancy, 54035 Nancy, France.
出版信息
Therapie. 2018 May-Jun;73(3):193-198. doi: 10.1016/j.therap.2017.10.005. Epub 2017 Nov 16.
INTRODUCTION
Intravenous iron infusion may be complicated by extravasation and lead to cutaneous pigmentation.
METHODS
We queried the French pharmacovigilance database to assess the spontaneously reported cases over the 2000-2016 period.
RESULTS
Fifty-one cases of cutaneous pigmentation related to intravenous iron extravasation were retrieved, none was associated to necrosis. Most of patients were women aged 20 to 49 years old. The pigmentation was mostly a brown coloration, persisting over one month in 19 cases (37.2%) and over 6 months in 9 cases (17.6%). The management of extravasation and pigmentation was heterogeneous and was rarely followed by a decrease of the coloration.
CONCLUSION
Cutaneous pigmentation after intravenous iron extravasation can persist over time and create an aesthetic prejudice, particularly in young women. Standardized extravasation and iron-induced pigmentation management procedures appear necessary.
引言
静脉注射铁剂可能会因渗漏而引发并发症，并导致皮肤色素沉着。
方法
我们查询了法国药物警戒数据库，以评估2000年至2016年期间自发报告的病例。
结果
共检索到51例与静脉注射铁剂渗漏相关的皮肤色素沉着病例，无一例与坏死有关。大多数患者为20至49岁的女性。色素沉着大多呈棕色，19例（37.2%）持续超过1个月，9例（17.6%）持续超过6个月。渗漏和色素沉着的处理方法各异，色素沉着很少会减轻。
结论
静脉注射铁剂渗漏后的皮肤色素沉着可能会长期存在，并造成美观问题，尤其是在年轻女性中。似乎有必要制定标准化的渗漏及铁剂所致色素沉着的处理程序。
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