抗原特异性CD4 T细胞的基因谱分析与T细胞受体测序
Gene Profiling and T Cell Receptor Sequencing from Antigen-Specific CD4 T Cells.
作者信息
Holt Marie, Costanzo Anne, Gioia Louis, Abe Brian, Su Andrew I, Teyton Luc
机构信息
Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
出版信息
Methods Mol Biol. 2018;1712:217-238. doi: 10.1007/978-1-4939-7514-3_14.
The paucity of pathogenic T cells in circulating blood limits the information delivered by bulk analysis. Toward diagnosis and monitoring of treatments of autoimmune diseases, we have devised single-cell analysis approaches capable of identifying and characterizing rare circulating CD4 T cells.
循环血液中致病性T细胞数量稀少，限制了整体分析所提供的信息。为了实现自身免疫性疾病的诊断和治疗监测，我们设计了单细胞分析方法，能够识别和表征罕见的循环CD4 T细胞。
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