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虚拟手部动作的执行、观察或模仿会对镜像神经元系统和默认模式网络的不同区域产生影响。

Action, observation or imitation of virtual hand movement affect differently regions of the mirror neuron system and the default mode network.

机构信息

ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France.

Department of Rehabilitation and Physical Medicine, Pôle Neurosciences, Centre Hospitalier Universitaire de Toulouse CHU, Toulouse, France.

出版信息

Brain Imaging Behav. 2018 Oct;12(5):1363-1378. doi: 10.1007/s11682-017-9804-x.

Abstract

Virtual reality (VR)-based paradigms use visual stimuli that can modulate visuo-motor networks leading to the stimulation of brain circuits. The aims of this study were to compare the changes in blood-oxygenation level dependent (BOLD) signal when watching and imitating moving real (RH) and virtual hands (VH) in 11 healthy participants (HP). No differences were found between the observation of RH or VH making this VR-based experiment a promising tool for rehabilitation protocols. VH-imitation involved more the ventral premotor cortex (vPMC) as part of the mirror neuron system (MNS) compared to execution and VH-observation conditions. The dorsal-anterior Precuneus (da-Pcu) as part of the Precuneus/posterior Cingulate Cortex (Pcu/pCC) complex, a key node of the Default Mode Network (DMN), was also less deactivated and therefore more involved. These results may reflect the dual visuo-motor roles for the vPMC and the implication of the da-Pcu in the reallocation of attentional and neural resources for bimodal task management. The ventral Pcu/pCC was deactivated regardless of the condition confirming its role in self-reference processes. Imitation of VH stimuli can then modulate the activation of specific areas including those belonging to the MNS and the DMN.

摘要

虚拟现实 (VR) 范式使用视觉刺激,可以调节视动网络,从而刺激大脑回路。本研究的目的是比较 11 名健康参与者 (HP) 在观看和模仿真实手 (RH) 和虚拟手 (VH) 运动时血氧水平依赖 (BOLD) 信号的变化。RH 和 VH 的观察没有发现差异,这使得基于 VR 的实验成为康复协议的有前途的工具。与执行和 VH 观察条件相比,VH 模仿涉及更多的腹侧前运动皮层 (vPMC),作为镜像神经元系统 (MNS) 的一部分。背侧前楔前叶 (da-Pcu) 作为楔前叶/后扣带皮层 (Pcu/pCC) 复合体的一部分,是默认模式网络 (DMN) 的关键节点,也较少去激活,因此更多地参与其中。这些结果可能反映了 vPMC 的双重视动作用,以及 da-Pcu 在双模态任务管理中重新分配注意力和神经资源的作用。腹侧 Pcu/pCC 无论在何种条件下均被去激活,证实了其在自我参照过程中的作用。因此,对 VH 刺激的模仿可以调节特定区域的激活,包括属于 MNS 和 DMN 的区域。

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