[Interhormonal relations in the dynamics of immune response during thyroidectomy].

Wistar rats were immunized with the sheep erythrocytes (SE) within 18 or 60 days after thyroidectomy. The latter led to a sharp drop in concentration of T3, T4 and to 2-3-fold increase in the TTH level. The SE administration failed to induce an increase in the T3, T4 level in operated animals whereas the TTH concentration increased. During the inductive period of immunogenesis a reduction occurred in the antigen-induced glycocorticoid response and the testosterone level in the early period replaced by their increase in later stages after the operation. The intensity of antibody production decreased in the early period and increased later. The data obtained suggest a participation of these changes of the endocrine functions in the mechanisms of thyroidectomy-induced disorders of the immune response.