地西他滨联合IAG方案治疗老年骨髓增生异常综合征（MDS）转化的急性髓系白血病的疗效
[Curative Effect of Decitabine Combined with IAG Regimen for Senile Patients with Myelodysplastic Syndrome (MDS) Transformed Acute Myeloid Leukemia].
作者信息
Huang Yue-Qin, Zhang Xue-Ya, Wu Shi-Xin, Guo Xi-Zhe, Pan Jing-Xin
机构信息
Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China.
Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China. E-mail:
出版信息
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Dec;25(6):1641-1646. doi: 10.7534/j.issn.1009-2137.2017.06.011.
OBJECTIVE
To investigate the curative effect and safety of decitabine combined with IAG regimen for treating senile MDS-transformed AML patients.
METHODS
Two cases of senile MDS-transformed AML were treated with decitabine combined with IAG regimen (decitabine 25 mg/d,qd,ivgtt,d1-5,Idarubicin 10 mg/d,qd,ivgtt,d6,Ara-C 10 mg/m,q12h, sc,d 6-19,G-CSF 300 µg,qd,ih,d6-19). The efficacy and adverse reactions were observed in these cases.
RESULTS
1 case for 2 courses and 1 case for 1 course obtained complete remission(CR). The myelosuppression and infections due to neutropenia were the most frequent adverse effects, the severe nonhematologic toxicity, such as liver and kidney and gastrointestinal reactions, were not observed in these patients.
CONCLUSION
Decitabine combined with IAG regimen is an effective for treating senile MDS-transformed AML patients.
目的
探讨地西他滨联合IAG方案治疗老年骨髓增生异常综合征转化的急性髓系白血病患者的疗效及安全性。
方法
2例老年骨髓增生异常综合征转化的急性髓系白血病患者采用地西他滨联合IAG方案治疗（地西他滨25mg/d，静脉滴注，qd，d1-5；去甲氧柔红霉素10mg/d，静脉滴注，qd，d6；阿糖胞苷10mg/m，皮下注射，q12h，d6-19；粒细胞集落刺激因子300μg，皮下注射，qd，d6-19）。观察这些患者的疗效及不良反应。
结果
1例完成2个疗程，1例完成1个疗程后获得完全缓解（CR）。骨髓抑制及中性粒细胞减少所致感染是最常见的不良反应，未观察到严重的非血液学毒性，如肝、肾及胃肠道反应。
结论
地西他滨联合IAG方案治疗老年骨髓增生异常综合征转化的急性髓系白血病患者有效。
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