Uquillas E, Dart C M, Perkins N R, Dart A J
Research and Clinical Trials Unit, University Veterinary Teaching Hospital Camden, School of Veterinary Science, University of Sydney, 410 Werombi Road, Camden, New South Wales, 2570, Australia.
School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia.
Aust Vet J. 2018 Jan;96(1-2):46-53. doi: 10.1111/avj.12662. Epub 2017 Dec 19.
To compare the effects of two concentrations of oxygen delivered to the anaesthetic breathing circuit on oxygenation in mechanically ventilated horses anaesthetised with isoflurane and positioned in dorsal or lateral recumbency.
Selected respiratory parameters and blood lactate were measured and oxygenation indices calculated, before and during general anaesthesia, in 24 laterally or dorsally recumbent horses. Horses were randomly assigned to receive 100% or 60% oxygen during anaesthesia. All horses were anaesthetised using the same protocol and intermittent positive pressure ventilation (IPPV) was commenced immediately following anaesthetic induction and endotracheal intubation. Arterial blood gas analysis was performed and oxygenation indices calculated before premedication, immediately after induction, at 10 and 45 min after the commencement of mechanical ventilation, and in recovery.
During anaesthesia, the arterial partial pressure of oxygen was adequate in all horses, regardless of position of recumbency or the concentration of oxygen provided. At 10 and 45 min after commencing IPPV, the arterial partial pressure of oxygen was lower in horses in dorsal recumbency compared with those in lateral recumbency, irrespective of the concentration of oxygen supplied. Based on oxygenation indices, pulmonary function during general anaesthesia in horses placed in dorsal recumbency was more compromised than in horses in lateral recumbency, irrespective of the concentration of oxygen provided.
During general anaesthesia, using oxygen at a concentration of 60% instead of 100% maintains adequate arterial oxygenation in horses in dorsal or lateral recumbency. However, it will not reduce pulmonary function abnormalities induced by anaesthesia and recumbency.
比较两种输送至麻醉呼吸回路的氧气浓度，对异氟烷麻醉且处于仰卧或侧卧体位的机械通气马匹氧合作用的影响。
在全身麻醉前及麻醉期间，对24匹侧卧或仰卧的马匹测量选定的呼吸参数和血乳酸，并计算氧合指数。马匹在麻醉期间被随机分配接受100%或60%的氧气。所有马匹均采用相同方案进行麻醉，麻醉诱导和气管插管后立即开始间歇正压通气（IPPV）。在麻醉前用药前、诱导后即刻、机械通气开始后10分钟和45分钟以及恢复时进行动脉血气分析并计算氧合指数。
在麻醉期间，所有马匹的动脉血氧分压均充足，无论其卧位或所提供氧气的浓度如何。在开始IPPV后10分钟和45分钟时，仰卧位马匹的动脉血氧分压低于侧卧位马匹，与所供应氧气的浓度无关。基于氧合指数，无论所提供氧气的浓度如何，仰卧位马匹在全身麻醉期间的肺功能比侧卧位马匹更易受损。
在全身麻醉期间，使用60%而非100%的氧气浓度可维持仰卧或侧卧马匹充足的动脉氧合。然而，它不会减少麻醉和卧位引起的肺功能异常。
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