进行性核上性麻痹的荟萃分析功能连接特征
Characterisation of meta-analytical functional connectivity in progressive supranuclear palsy.
作者信息
Yu F, Barron D S, Tantiwongkosi B, Fox M, Fox P
机构信息
Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA.
Department of Psychiatry, Yale School of Medicine, 333 Cedar St., New Haven, CT 06510, USA.
出版信息
Clin Radiol. 2018 Apr;73(4):415.e1-415.e7. doi: 10.1016/j.crad.2017.11.007. Epub 2017 Dec 18.
AIM
To characterise the meta-analytical functional connectivity patterns in progressive supranuclear palsy (PSP) and compare them to idiopathic Parkinson's disease (IPD).
MATERIALS AND METHODS
It was previously reported that PSP and IPD showed distinct regions of brain atrophy based on voxel-based morphometry (VBM) meta-analysis. Using these regions as seeds, healthy control data were referenced to create and statistically compare meta-analytical functional connectivity maps of PSP and IPD.
RESULTS
Some overlap was noted between the two diseases, including within the thalamus, striatum, and prefrontal cortex; however, the PSP seeds demonstrated more extensive functional co-activity throughout the brain, particularly within the midbrain, precentral gyrus, parietal cortex, basal ganglia, and cerebellum.
CONCLUSION
These findings may help guide future longitudinal studies in the development of new functional imaging biomarkers for diagnosis and assessing treatment response.
目的
描绘进行性核上性麻痹（PSP）的荟萃分析功能连接模式，并将其与特发性帕金森病（IPD）进行比较。
材料与方法
先前基于体素形态学（VBM）荟萃分析报道，PSP和IPD表现出不同的脑萎缩区域。以这些区域为种子点，参考健康对照数据来创建并统计比较PSP和IPD的荟萃分析功能连接图。
结果
两种疾病之间存在一些重叠，包括丘脑、纹状体和前额叶皮质内；然而，PSP的种子点在整个大脑中表现出更广泛的功能共同活动，特别是在中脑、中央前回、顶叶皮质、基底神经节和小脑中。
结论
这些发现可能有助于指导未来的纵向研究，以开发用于诊断和评估治疗反应的新功能成像生物标志物。
Zotero 插件