Seek and You Will Not Find: Ending the Hunt for Replication-Competent Retroviruses during Human Gene Therapy.

作者信息

Heslop Helen E, Brenner Malcolm K

机构信息

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.

出版信息

Mol Ther. 2018 Jan 3;26(1):1-2. doi: 10.1016/j.ymthe.2017.12.004. Epub 2017 Dec 20.

DOI:10.1016/j.ymthe.2017.12.004

PMID:29273500

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5763151/

Abstract

摘要

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本文引用的文献

[1]

Absence of Replication-Competent Retrovirus in Vectors, T Cell Products, and Patient Follow-Up Samples.

Mol Ther. 2018-1-3

[2]

Retroviral and Lentiviral Safety Analysis of Gene-Modified T Cell Products and Infused HIV and Oncology Patients.

Mol Ther. 2017-10-20

[3]

Absence of Replication-Competent Lentivirus in the Clinic: Analysis of Infused T Cell Products.

Mol Ther. 2017-9-12

[4]

Next Steps in the CAR Journey of a Thousand Miles.

Mol Ther. 2017-10-4

[5]

Tragedy, Perseverance, and Chance - The Story of CAR-T Therapy.

N Engl J Med. 2017-10-5

[6]

Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements?

Mol Ther. 2012-2

[7]

Replication-competent lentivirus analysis of clinical grade vector products.

Mol Ther. 2010-12-21

[8]

Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer.

J Exp Med. 1992-10-1

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Seek and You Will Not Find: Ending the Hunt for Replication-Competent Retroviruses during Human Gene Therapy.

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