Northeastern University, Department of Chemistry and Chemical Biology, 102 Hurtig Hall, 360 Huntington Avenue, Boston, MA 02115, USA.
Trends Parasitol. 2018 Mar;34(3):178-179. doi: 10.1016/j.pt.2017.12.002. Epub 2017 Dec 20.
Decades after the last new chemical entity was added to the pharmacopeia for human African trypanosomiasis (or sleeping sickness), orally dosed fexinidazole stands poised to replace the current treatment regimen for Trypanosoma brucei gambiense infections, following a positive Phase 2/3 clinical trial.
在最后一种新的化学实体被添加到人类非洲锥虫病(或昏睡病)的药典中几十年后,在一项阳性的 2/3 期临床试验之后,口服芬苯达唑有望取代目前针对冈比亚锥虫感染的治疗方案。