缺氧诱导因子表达与血管生成——垂体分析及死亡模式
Hypoxia Inducible Factor Expression and Angiogenesis - Analysis in the Pituitary Gland and Patterns of Death.
作者信息
Kouroupi Maria, Sivridis Efthimios, Papazoglou Dimitrios, Koukourakis Michael I, Giatromanolaki Alexandra
机构信息
Department of Pathology, University General Hospital of Alexandroupolis/Democritus University of Thrace, Alexandroupolis, Greece.
Department of Internal Medicine, University General Hospital of Alexandroupolis/Democritus University of Thrace, Alexandroupolis, Greece.
出版信息
In Vivo. 2018 Jan-Feb;32(1):185-190. doi: 10.21873/invivo.11223.
BACKGROUND/AIM: We investigated the expression of angiogenesis and hypoxia markers in the adenohypophysis and neurohypophysis of patients who died from various acute or chronic diseases.
MATERIALS AND METHODS
Paraffin-embedded material of pituitary glands (97 patients) was investigated immunohistochemically for vascular density (CD31) and the expression of vascular endothelial growth factor (VEGF) and of hypoxia inducible factors HIF1α and HIF2α.
RESULTS
Vascular density, and HIF1α/HIF2α reactivity is directly related with VEGF expression in the pituitary gland, suggesting that the HIF pathway may regulate the vascular density and blood flow in the gland under hypoxic conditions. HIF2α appears to be a key regulator in neurohypophysis, whilst in adenohypophysis HIF1α and HIF2α are equally expressed. Chronic conditions, including alcoholism and substance abuse, seem to activate the HIF pathway in both neuro- and adeno-hypophysis.
CONCLUSION
The HIF pathway has an important role in regulating vascular density and blood flow in the pituitary gland.
背景/目的：我们研究了因各种急性或慢性疾病死亡患者的腺垂体和神经垂体中血管生成及缺氧标志物的表达情况。
材料与方法
对97例患者垂体的石蜡包埋材料进行免疫组织化学研究，检测血管密度（CD31）、血管内皮生长因子（VEGF）以及缺氧诱导因子HIF1α和HIF2α的表达。
结果
垂体中的血管密度以及HIF1α/HIF2α反应性与VEGF表达直接相关，这表明在缺氧条件下，HIF通路可能调节垂体中的血管密度和血流。HIF2α似乎是神经垂体中的关键调节因子，而在腺垂体中HIF1α和HIF2α表达相当。包括酗酒和药物滥用在内的慢性疾病似乎会激活神经垂体和腺垂体中的HIF通路。
结论
HIF通路在调节垂体中的血管密度和血流方面具有重要作用。
Zotero 插件