神经肌肉接头的组成、发育和再生。
The Composition, Development, and Regeneration of Neuromuscular Junctions.
机构信息
Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United States.
Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United States; Stem Cell and Regenerative Medicine Institute, University of Rochester Medical Center, Rochester, NY, United States; The Rochester Aging Research Center, University of Rochester Medical Center, Rochester, NY, United States.
出版信息
Curr Top Dev Biol. 2018;126:99-124. doi: 10.1016/bs.ctdb.2017.08.005. Epub 2017 Nov 10.
The neuromuscular junction (NMJ) is the specialized site that connects the terminal of a motor neuron axon to skeletal muscle. As a synapse NMJ integrity is essential for transducing motor neuron signals that initiate skeletal muscle contraction. Many diseases and skeletal muscle aging are linked to impaired NMJ function and the associated muscle wasting. In this chapter we review the components of an NMJ and, the processes of NMJ development, maturation, and regeneration. Also, we briefly discuss the cellular and molecular mechanisms of NMJ decline in the context of disease and aging.
神经肌肉接头（NMJ）是连接运动神经元轴突末端到骨骼肌的特化部位。作为一个突触，NMJ 的完整性对于传递启动骨骼肌收缩的运动神经元信号至关重要。许多疾病和骨骼肌衰老都与 NMJ 功能障碍和相关的肌肉萎缩有关。本章回顾了 NMJ 的组成部分，以及 NMJ 的发育、成熟和再生过程。此外，我们还简要讨论了疾病和衰老背景下 NMJ 衰退的细胞和分子机制。
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