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强亚阈跨模态调制听觉反应的经皮电刺激在第一和高阶听觉丘脑核。

Robust Subthreshold Cross-modal Modulation of Auditory Response by Cutaneous Electrical Stimulation in First- and Higher-order Auditory Thalamic Nuclei.

机构信息

Department of Physiology, Wakayama Medical University, Wakayama Kimiidera 811-1, 641-8509, Japan.

Department of Physiology, Wakayama Medical University, Wakayama Kimiidera 811-1, 641-8509, Japan.

出版信息

Neuroscience. 2018 Feb 21;372:161-180. doi: 10.1016/j.neuroscience.2017.12.051. Epub 2018 Jan 6.

Abstract

Conventional extracellular recording has revealed cross-modal alterations of auditory cell activities by cutaneous electrical stimulation of the hindpaw in first- and higher-order auditory thalamic nuclei (Donishi et al., 2011). Juxta-cellular recording and labeling techniques were used in the present study to examine the cross-modal alterations in detail, focusing on possible nucleus and/or cell type-related distinctions in modulation. Recordings were obtained from 80 cells of anesthetized rats. Cutaneous electrical stimulation, which did not elicit unit discharges, i.e., subthreshold effects, modulated early (onset) and/or late auditory responses of first- (64%) and higher-order nucleus cells (77%) with regard to response magnitude, latency and/or burst spiking. Attenuation predominated in the modulation of response magnitude and burst spiking, and delay predominated in the modulation of response time. Striking alterations of burst spiking took place in higher-order nucleus cells, which had the potential to exhibit higher propensities for burst spiking as compared to first-order nucleus cells. A subpopulation of first-order nucleus cells showing modulation in early response magnitude in the caudal domain of the nucleus had larger cell bodies and higher propensities for burst spiking as compared to cells showing no modulation. These findings suggest that somatosensory influence is incorporated into parallel channels in auditory thalamic nuclei to impose distinct impacts on cortical and subcortical sensory processing. Further, cutaneous electrical stimulation given after early auditory responses modulated late responses. Somatosensory influence is likely to affect ongoing auditory processing at any time without being coincident with sound onset in a narrow temporal window.

摘要

传统的细胞外记录已经揭示了通过后足底的皮肤电刺激对初级和高级听觉丘脑核中的听觉细胞活动的跨模态改变(Donishi 等人,2011 年)。本研究使用细胞内记录和标记技术来详细检查跨模态改变,重点关注可能与核和/或细胞类型相关的调制区别。记录来自麻醉大鼠的 80 个细胞。皮肤电刺激不会引起单位放电,即亚阈值效应,调节了初级(起始)和/或高级核细胞(77%)的听觉反应的早期(起始)和/或晚期,涉及反应幅度、潜伏期和/或爆发性尖峰。衰减在反应幅度和爆发性尖峰的调制中占主导地位,而延迟在反应时间的调制中占主导地位。爆发性尖峰的显著改变发生在高级核细胞中,与初级核细胞相比,这些细胞具有更高的爆发性尖峰倾向。具有在核的尾部区域中早期反应幅度调制的初级核细胞的亚群具有更大的细胞体和更高的爆发性尖峰倾向,而没有调制的细胞则没有。这些发现表明,躯体感觉的影响被整合到听觉丘脑核的平行通道中,对皮质和皮质下感觉处理产生不同的影响。此外,早期听觉反应之后的皮肤电刺激调制了晚期反应。躯体感觉的影响可能在任何时候都在影响正在进行的听觉处理,而不是与声音起始在狭窄的时间窗口内同时发生。

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