DSP 中 MGUS 的高频率。

High frequency of MGUS in DSP.

机构信息

Neuromuscular Service of the Department of Neurology, Tel Aviv Sourasky Medical Center, the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.

出版信息

Muscle Nerve. 2018 Jun;57(6):1018-1021. doi: 10.1002/mus.26054. Epub 2018 Feb 2.

DOI:10.1002/mus.26054

PMID:29314079

Abstract

INTRODUCTION

Monoclonal gammopathy has been reported in several polyneuropathies. In this study, we sought to explore the frequency and characteristics of monoclonal gammopathy in patients with diabetic sensorimotor polyneuropathy (DSP).

METHODS

Patients with type 1 and type 2 diabetes mellitus (DM 1, DM 2) and controls without diabetes were evaluated between November 2008 and December 2013.

RESULTS

Fifty controls, 66 patients with DM 1, and 106 patients with DM 2 were included, with average ages of 43 ± 18, 45 ± 17, and 65 ± 10 years, respectively; the frequency of monoclonal gammopathy was 0%, 8%, and 15%, respectively. In patients with DSP, the frequency of monoclonal gammopathy increased to 14% in DM 1 and 21% in DM 2; the most common monoclonal proteins were immunoglobulin (Ig) M and IgG, respectively.

DISCUSSION

DSP might be associated with a high frequency of monoclonal gammopathy, with different characteristics in DM 1 and in DM 2. Muscle Nerve 57: 1018-1021, 2018.

摘要

简介

单克隆丙种球蛋白血症已在几种多发性神经病中被报道。在这项研究中，我们试图探讨单克隆丙种球蛋白血症在糖尿病感觉运动性多发性神经病（DSP）患者中的发生频率和特征。

方法

在 2008 年 11 月至 2013 年 12 月期间，评估了 1 型和 2 型糖尿病（DM1、DM2）患者和无糖尿病对照者。

结果

共纳入 50 名对照者、66 名 DM1 患者和 106 名 DM2 患者，平均年龄分别为 43±18、45±17 和 65±10 岁；单克隆丙种球蛋白血症的发生率分别为 0%、8%和 15%。在 DSP 患者中，DM1 患者中单克隆丙种球蛋白血症的发生率增至 14%，DM2 患者增至 21%；最常见的单克隆蛋白分别为免疫球蛋白（Ig）M 和 IgG。