黑色素瘤发展的途径。

Pathways in melanoma development.

作者信息

Erlich Tal H, Fisher David E

机构信息

Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA -

出版信息

G Ital Dermatol Venereol. 2018 Feb;153(1):68-76. doi: 10.23736/S0392-0488.17.05795-9.

DOI:10.23736/S0392-0488.17.05795-9

PMID:29319276

Abstract

This review aimed to summarize the current advances in melanoma research and their clinical relevance. Until recently, melanoma was considered an incurable disease. However, in recent years tremendous advances have been made in therapeutics. This is due to profound understanding of the molecular pathways involved in melanoma development. Although new targets are always emerging, understanding how to overcome resistance to current treatments is of great interest.

摘要

本综述旨在总结黑色素瘤研究的当前进展及其临床相关性。直到最近，黑色素瘤还被认为是一种无法治愈的疾病。然而，近年来在治疗方面取得了巨大进展。这是由于对黑色素瘤发展所涉及的分子途径有了深刻的理解。尽管新的靶点不断涌现，但了解如何克服对当前治疗的耐药性仍备受关注。