Fitzgerald R E, Oettinger R, Bättig K
Pharmacol Biochem Behav. 1985 Aug;23(2):279-84. doi: 10.1016/0091-3057(85)90570-2.
Spontaneous locomotion of female Wistar rats was measured in six to ten minute sessions in an automated tunnel maze consisting of a central arena and six radially symmetrical angled arms. Nicotine (0.2 mg/kg subcutaneous, 20-30 minutes pretest) increased total arm visit frequency, but intrasession habituation and number of repetitive arm visits in the first six choices were not affected. pCPA (300 mg/kg IP three days pretest) reduced arm-visit frequency in nicotine-, but not in saline-treated rats; it had no effect on intrasession habituation or number of repetitions in either treatment group. 5-HTP (50 mg/kg IP 90 minutes pretest) reduced arm entry frequency in saline-, nicotine-, and pCPA-treated groups. Possible reasons for this discrepancy are discussed.
在一个由中央竞技场和六条呈放射状对称倾斜臂组成的自动隧道迷宫中，对雌性Wistar大鼠的自发运动进行了6至10分钟的测量。尼古丁（皮下注射0.2mg/kg，测试前20 - 30分钟）增加了总臂访问频率，但在前六个选择中的会话内习惯化和重复臂访问次数不受影响。对氯苯丙氨酸（测试前三天腹腔注射300mg/kg）降低了尼古丁处理大鼠的臂访问频率，但对生理盐水处理的大鼠没有影响；它对两个处理组的会话内习惯化或重复次数均无影响。5 - 羟色氨酸（测试前90分钟腹腔注射50mg/kg）降低了生理盐水、尼古丁和对氯苯丙氨酸处理组的臂进入频率。讨论了这种差异的可能原因。
