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基于镥背景活性的刚性 MR 发射/接收线圈的 PET 衰减校正。

PET attenuation correction for rigid MR Tx/Rx coils from Lu background activity.

机构信息

Medical Imaging Physics Department, Institute for Neuroscience and Medicine (INM-4), Forschungszentrum Jülich GmbH, Jülich, Germany.

出版信息

Phys Med Biol. 2018 Feb 6;63(3):035039. doi: 10.1088/1361-6560/aaa72a.

Abstract

One challenge for PET-MR hybrid imaging is the correction for attenuation of the 511 keV annihilation radiation by the required RF transmit and/or RF receive coils. Although there are strategies for building PET transparent Tx/Rx coils, such optimised coils still cause significant attenuation of the annihilation radiation leading to artefacts and biases in the reconstructed activity concentrations. We present a straightforward method to measure the attenuation of Tx/Rx coils in simultaneous MR-PET imaging based on the natural Lu background contained in the scintillator of the PET detector without the requirement of an external CT scanner or PET scanner with transmission source. The method was evaluated on a prototype 3T MR-BrainPET produced by Siemens Healthcare GmbH, both with phantom studies and with true emission images from patient/volunteer examinations. Furthermore, the count rate stability of the PET scanner and the x-ray properties of the Tx/Rx head coil were investigated. Even without energy extrapolation from the two dominant γ energies of Lu to 511 keV, the presented method for attenuation correction, based on the measurement of Lu background attenuation, shows slightly better performance than the coil attenuation correction currently used. The coil attenuation correction currently used is based on an external transmission scan with rotating Ge sources acquired on a Siemens ECAT HR  +  PET scanner. However, the main advantage of the presented approach is its straightforwardness and ready availability without the need for additional accessories.

摘要

PET-MR 混合成像面临的一个挑战是需要校正由所需的 RF 发射和/或 RF 接收线圈引起的 511keV 湮没辐射衰减。尽管有构建 PET 透明 Tx/Rx 线圈的策略,但这种优化的线圈仍然会导致湮没辐射的显著衰减,从而在重建的活性浓度中产生伪影和偏差。我们提出了一种简单的方法,用于在基于 PET 探测器闪烁体中包含的自然 Lu 背景的同时 MR-PET 成像中测量 Tx/Rx 线圈的衰减,而无需外部 CT 扫描仪或具有传输源的 PET 扫描仪。该方法在由 Siemens Healthcare GmbH 生产的原型 3T MR-BrainPET 上进行了评估,包括 phantom 研究和来自患者/志愿者检查的真实发射图像。此外,还研究了 PET 扫描仪的计数率稳定性和 Tx/Rx 头线圈的 X 射线特性。即使没有从 Lu 的两个主要 γ 能量推断到 511keV 的能量外推,基于 Lu 背景衰减测量的衰减校正方法的性能也略优于当前使用的线圈衰减校正。当前使用的线圈衰减校正方法基于在 Siemens ECAT HR  +  PET 扫描仪上使用旋转 Ge 源进行的外部透射扫描。然而,所提出方法的主要优点是其简单性和可用性,无需额外的附件。

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