Guerriero Réjean M, Kuemmerle Karameh, Pepin Michael J, Taylor Alex M, Wolff Robert, Meehan William P
1 Department of Neurology, Boston Children's Hospital & Harvard Medical School, Boston, MA, USA.
2 Departments of Neurology, Division of Pediatric and Developmental Neurology, Washington University School of Medicine, St. Louis, MO, USA.
J Child Neurol. 2018 Feb;33(2):168-173. doi: 10.1177/0883073817749655.
The association between preexisting anxiety, depression, and/or neurodevelopmental disorders and symptom duration among younger children who sustain concussions is not well known. The authors conducted a prospective cohort study of 569 patients presenting to a pediatric neurology clinic with the diagnosis of concussion. The authors measured associations between symptom duration and premorbid conditions, as well as gender, age, mechanism of injury, and other factors. Premorbid conditions were common in both age groups. On univariate modeling female gender, age >12 years, and premorbid conditions were associated with longer symptom duration. On multivariable modeling, females and patients ≤12 years old with a history of headaches, migraines, or a history of psychiatric conditions took significantly longer to recover than those without such conditions. Premorbid conditions are associated with a prolonged recovery from concussion among those patients ≤12 years old.
既往存在焦虑、抑郁和/或神经发育障碍与遭受脑震荡的年幼儿童症状持续时间之间的关联尚不清楚。作者对569名到儿科神经科诊所就诊且被诊断为脑震荡的患者进行了一项前瞻性队列研究。作者测量了症状持续时间与病前状况以及性别、年龄、损伤机制和其他因素之间的关联。病前状况在两个年龄组中都很常见。单变量模型显示,女性、年龄>12岁和病前状况与较长的症状持续时间相关。多变量模型显示,有头痛、偏头痛病史或精神疾病史的女性和≤12岁的患者比没有这些情况的患者恢复时间明显更长。病前状况与≤12岁的脑震荡患者恢复时间延长有关。