20 年前因受污染的献血或输血而感染 HIV-1 的长期非进展者和病毒血症控制者的特征。
Characteristics of Long-term Nonprogressors and Viremia Controllers Infected with HIV-1 via Contaminated Blood Donations or Transfusions Conducted 20 Years Earlier.
机构信息
Institute for Prevention and Control of AIDS and STD, Henan Center for Disease Control and Prevention, Zhengzhou 450016, Henan, China.
出版信息
Biomed Environ Sci. 2017 Dec;30(12):907-912. doi: 10.3967/bes2017.121.
To characterize long-term nonprogressors (LTNPs) and viremia controllers (VCs), infected with HIV-1 through contaminated blood donation or transfusion between 1992 and 1996 in Henan, China. LTNPs and VCs were defined by CD4+T lymphocyte (CD4) count and viral load (VL). Of 29,294 patients infected with HIV-1 via contaminated blood donation or transfusion that had conducted for more than 20 years, 92 were LTNPs/VCs. There were 70 LTNPs (0.24%), 43 VCs (0.15%), and 48 LTNPs+VCs- (0.16%). VCs had a significantly lower CD4 nadir, compared to LTNPs and LTNPs+VCs-, and no significant differences for the highest VL and HIV-1 DNA. Cases P4 and P5 were LTNPs, while their VL reached approximately 4.3 log copies/mL. P6 was a VC, but with CD4 < 500 cells/μL constantly. Data from the LTNPs/VCs cohort provided valuable information, future research is needed.
为了描述在中国河南，1992 年至 1996 年间通过受污染的献血或输血感染 HIV-1 的长期非进展者（LTNPs）和病毒血症控制者（VCs）。LTNPs 和 VCs 通过 CD4+T 淋巴细胞（CD4）计数和病毒载量（VL）来定义。在经过 20 多年以上的调查中，有 92 例是 LTNPs/VCs。其中，70 例为 LTNPs（0.24%），43 例为 VCs（0.15%），48 例为 LTNPs+VCs-（0.16%）。与 LTNPs 和 LTNPs+VCs-相比，VCs 的 CD4 最低点明显较低，而最高 VL 和 HIV-1 DNA 没有显著差异。病例 P4 和 P5 是 LTNPs，但其 VL 达到约 4.3 对数拷贝/mL。病例 P6 是一个 VC，但 CD4 持续低于 500 个细胞/μL。LTNPs/VCs 队列的数据提供了有价值的信息，需要进一步研究。
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