Wong Eugene, Nahar Najmun, Hau Eric, Varikatt Winny, Gebski Val, Ng Thomas, Jayamohan Jayasingham, Sundaresan Puma
Sydney Medical School, University of Sydney, Sydney, Australia.
Royal North Shore Hospital, St Leonards, NSW, Australia.
Asia Pac J Clin Oncol. 2019 Feb;15(1):5-9. doi: 10.1111/ajco.12826. Epub 2018 Jan 16.
Ki-67 proliferation index (Ki-67 index) is used to quantify cell proliferation during histopathological assessment of various tumors including glioblastoma (GB).
We aimed to assess correlation between Ki-67 index and overall survival in patients with GB and determine a cut-point for Ki-67 index that predicts for poorer survival.
Records of adult patients diagnosed with GB on histopathological specimens at a tertiary cancer center in Sydney between 1 January 2002 and 30 July 2012 were retrieved. Specimens of these patients were examined for quantification of Ki-67 staining by two independent pathologists. Patient, disease, treatment, and survival data were collected from hospital and cancer care service records. Statistical analysis was performed using proportional hazards models, Kaplan-Meier curves, and the minimum P-value approach.
Of the eligible 71 patients, 58% were males with median age of 58 (range 18-87). Seventy-three percent of patients were of ECOG performance status 0-1. There was a statistically significant correlation between Ki-67 index and overall survival. In patients with Ki-67 > 22% (n = 36), 5-year survival was approximately 30% compared to 5% in those with Ki-67 ≤ 22% (n = 35; log-rank P-value = 0.04; hazard ratio (HR) = 0.53; 95% confidence intervals (CI), 0.29-0.97).
This study demonstrates a positive correlation between Ki-67 index and overall survival in patients with GB. Percentage staining of Ki-67 < 22% appears to predict for poorer survival in GB.
Ki-67增殖指数（Ki-67指数）用于在包括胶质母细胞瘤（GB）在内的各种肿瘤的组织病理学评估期间量化细胞增殖。
我们旨在评估GB患者中Ki-67指数与总生存期之间的相关性，并确定预测生存期较差的Ki-67指数切点。
检索2002年1月1日至2012年7月30日期间在悉尼一家三级癌症中心经组织病理学标本诊断为GB的成年患者记录。由两名独立病理学家检查这些患者的标本以量化Ki-67染色。从医院和癌症护理服务记录中收集患者、疾病、治疗和生存数据。使用比例风险模型、Kaplan-Meier曲线和最小P值法进行统计分析。
在符合条件的71例患者中，58%为男性，中位年龄为58岁（范围18 - 87岁）。73%的患者ECOG体能状态为0 - 1。Ki-67指数与总生存期之间存在统计学显著相关性。在Ki-67＞22%的患者（n = 36）中，5年生存率约为30%，而Ki-67≤22%的患者（n = 35）为5%（对数秩P值 = 0.04；风险比（HR） = 0.53；95%置信区间（CI），0.29 - 0.97）。
本研究表明GB患者中Ki-67指数与总生存期呈正相关。Ki-67染色百分比＜22%似乎可预测GB患者生存期较差。
