RE[N(SiMe)] 催化的氨基酸酯和碳二亚胺的胍基化/环化反应。
RE[N(SiMe)]-Catalyzed Guanylation/Cyclization of Amino Acid Esters and Carbodiimides.
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, People's Republic of China.
出版信息
J Org Chem. 2018 Feb 2;83(3):1154-1159. doi: 10.1021/acs.joc.7b02550. Epub 2018 Jan 23.
The example of rare-earth metal-catalyzed guanylation/cyclization of amino acid esters and carbodiimides is well-established, forming 4(3H)-2-alkylaminoquinazolinones in 65-96% yields. The rare-earth metal amides RE[N(TMS)] (RE = Y, Yb, Nd, Sm, La; TMS = SiMe) showed high activities, and La[N(TMS)] performed best for a wide scope of the substrates.
稀土金属催化的氨基酸酯和碳二亚胺的胍化/环化反应是一个很好的例子，该反应以 65-96%的产率生成 4(3H)-2-烷基氨基喹唑啉酮。稀土金属酰胺 RE[N(TMS)]（RE = Y、Yb、Nd、Sm、La；TMS = SiMe）表现出很高的活性，其中 La[N(TMS)]对广泛的底物表现出最佳性能。
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