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[心肌梗死的尸检解剖学研究与二维超声心动图的比较]

[Comparison of the postmortem anatomical study and bidimensional echocardiography in myocardial infarction].

作者信息

Esquivel-Avila J G, Ferrero L, González J A, Baez N, Osornio A R, Varela J

出版信息

Arch Inst Cardiol Mex. 1985 Jul-Aug;55(4):319-28.

PMID:2934032
Abstract

We studied 10 patients between the ages of 30 and 69 years, all of whom had suffered myocardial infarction (MI) at least 6 months before they died. Two-dimensional echocardiography (2-D E) and catheterism were done no more than 15 days before death. The location and extension of MI were compared to the segmentary mobility (SM), end diastolic wall thickness (EDWT) and percentage of systolic wall thickening (PSWT) determined by 2-D E, in the 15 segments of the left ventricular wall. We also compared 2-D E and coronariographic findings. There was a good correlation between the location (P less than 0.01) and extension (P less than 0.05) of the necrotic area dyssynergy, specially when the MI was transmural. The postmortem measurement of the wall thickness in each one of the segments had also good correlation with the EDWT as measured with 2-D E (r = 0.926). The EDWT was less in the necrotic segments (8.8 +/- 1.8 mm) than in non affected segments (14.1 +/- 1.9 mm) and this difference was significant (P less than 0.05). The wall was thinnest in segment affected by transmural necrosis. The PSWT was significantly less (P less than 0.01) in necrotic segments (12.1 +/- 3%) than in segments without necrosis (24.1 +/- 4.3%). The alteration of SM correlated with coronary obstructions greater than 75%, specially when it was associated with necrosis. The EDWT was less in necrotic segments with important coronary artery obstruction than in those without necrosis even though vascular narrowing was marked (P less than 0.01). The PSWT was also less in the areas with necrosis when coronary obstruction was severe as well as moderate (11.3 +/- 2.3%) than in segments with coronary obstruction but without necrosis (22.3 +/- 4.2%) and even less than that obtained in cases with neither coronary artery obstruction nor necrotic area (30.1 +/- 2.2%) and the difference is statistically significant (P less than 0.01). The segmentary measurement by 2-D E of the EDWT and the PSWT are useful for recognizing areas with necrosis and differentiating it from ischemic areas of left ventricle in coronary artery disease.

摘要

我们研究了10名年龄在30至69岁之间的患者,他们在死亡前至少6个月均发生过心肌梗死(MI)。在死亡前不超过15天进行了二维超声心动图(2-D E)检查和心导管检查。将心肌梗死的部位和范围与通过二维超声心动图测定的左心室壁15个节段的节段性运动(SM)、舒张末期室壁厚度(EDWT)和室壁增厚百分比(PSWT)进行比较。我们还比较了二维超声心动图和冠状动脉造影的结果。坏死区域运动失调的部位(P<0.01)和范围(P<0.05)之间存在良好的相关性,特别是当心肌梗死为透壁性时。每个节段的尸检室壁厚度测量值与二维超声心动图测量的舒张末期室壁厚度也具有良好的相关性(r = 0.926)。坏死节段的舒张末期室壁厚度(8.8±1.8mm)低于未受累节段(14.1±1.9mm),且差异具有统计学意义(P<0.05)。透壁坏死节段的室壁最薄。坏死节段的室壁增厚百分比(12.1±3%)显著低于无坏死节段(24.1±4.3%)(P<0.01)。节段性运动的改变与冠状动脉阻塞大于75%相关,特别是当伴有坏死时。即使血管狭窄明显,有重要冠状动脉阻塞的坏死节段的舒张末期室壁厚度也低于无坏死节段(P<0.01)。当冠状动脉阻塞严重及中度时,坏死区域的室壁增厚百分比(11.3±2.3%)也低于有冠状动脉阻塞但无坏死的节段(22.3±4.2%),甚至低于既无冠状动脉阻塞也无坏死区域的病例(30.1±2.2%),差异具有统计学意义(P<0.01)。二维超声心动图对舒张末期室壁厚度和室壁增厚百分比的节段性测量有助于识别坏死区域并将其与冠心病左心室缺血区域区分开来。

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