The Wistar Institute, Philadelphia, PA, USA.
Nat Immunol. 2018 Feb;19(2):108-119. doi: 10.1038/s41590-017-0022-x. Epub 2018 Jan 18.
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathologic conditions ranging from cancer to obesity. These cells represent a pathologic state of activation of monocytes and relatively immature neutrophils. MDSCs are characterized by a distinct set of genomic and biochemical features, and can, on the basis of recent findings, be distinguished by specific surface molecules. The salient feature of these cells is their ability to inhibit T cell function and thus contribute to the pathogenesis of various diseases. In this Review, we discuss the origin and nature of these cells; their distinctive features; and their biological roles in cancer, infectious diseases, autoimmunity, obesity and pregnancy.
髓系来源的抑制细胞（MDSCs）是在多种病理条件下产生的异质性细胞群体，范围从癌症到肥胖。这些细胞代表单核细胞和相对不成熟的中性粒细胞活化的病理状态。MDSCs 的特征在于其独特的基因组和生化特征，并且可以根据最近的发现，通过特定的表面分子来区分。这些细胞的显著特征是它们抑制 T 细胞功能的能力，从而有助于各种疾病的发病机制。在这篇综述中，我们讨论了这些细胞的起源和性质；它们的独特特征；以及它们在癌症、传染病、自身免疫、肥胖和妊娠中的生物学作用。
