• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

比较基于透明质酸的胶束和基于聚乙二醇的胶束对逆转多药耐药性和增强体内外抗肿瘤疗效的作用。

Comparison of hyaluronic acid-based micelles and polyethylene glycol-based micelles on reversal of multidrug resistance and enhanced anticancer efficacy in vitro and in vivo.

机构信息

a School of Chinese Materia Medica , Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing , PR China.

出版信息

Drug Deliv. 2018 Nov;25(1):330-340. doi: 10.1080/10717544.2018.1428385.

DOI:10.1080/10717544.2018.1428385
PMID:29350064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6058673/
Abstract

Polyethylene glycol (PEG)-based block copolymer micelles and hyaluronic acid (HA)-based grafted copolymer micelles have been widely investigated in chemotherapy. In this study, to evaluate the differences among HA-based grafted polymer micelles, PEG-based block polymer micelles and the mixed of these two micelles in enhancing antitumor effects and overcoming MDR, two amphiphilic vitamin E succinate (VES) derivatives, HA VES (HA-g-VES) and PEG 2000 VES (TPGS2k), were applied as nanocarriers to prepare HA-VES micelles (HA-PMs), TPGS2k micelles (TPGS2k-PMs) and the mixed micelles (HA/TPGS2k-PMs) for the co-delivery of doxorubicin (DOX) and curcumin (Cur). With the addition of TPGS2k, the particle size of HA/TPGS2k-PMs (153.37 ± 1.00 nm) was smaller than that of HA-PMs (223.83 ± 1.84) but significantly larger than that of TPGS2k-PMs (about 20 nm). The loading efficiency of HA/TPGS2k-PMs was 7.10%, which was lower than HA-PMs (8.31 ± 0.15%) but higher than TPGS2k-PMs (4.38 ± 0.24%). In vitro, HA/TPGS2k-PMs and TPGS2k-PMs exhibited higher cytotoxicity and reversal MDR effects than HA-PMs in MCF-7/Adr cells. However, HA/TPGS2k-PMs, HA-PMs and TPGS2k-PMs all significantly improved the tumor biodistribution, the antitumor effects and reduced the side effects of DOX in 4T1-tumor-bearing mice, but these three micelles displayed no differences in vivo. Therefore, EPR passive targeting effects caused by PEGylated micelles and CD44 active targeting effects caused by HA-based micelles have no significant variance in the delivery of antitumor drugs by i.v.

摘要

聚乙二醇（PEG）基嵌段共聚物胶束和透明质酸（HA）基接枝共聚物胶束已广泛应用于化疗领域。在这项研究中，为了评估基于 HA 的接枝聚合物胶束、PEG 基嵌段聚合物胶束以及这两种胶束混合物在增强抗肿瘤效果和克服多药耐药性方面的差异，我们将两种两亲性维生素 E 琥珀酸酯（VES）衍生物，HA VES（HA-g-VES）和 PEG 2000 VES（TPGS2k），用作纳米载体来制备 HA-VES 胶束（HA-PMs）、TPGS2k 胶束（TPGS2k-PMs）和混合胶束（HA/TPGS2k-PMs），以共递送阿霉素（DOX）和姜黄素（Cur）。随着 TPGS2k 的加入，HA/TPGS2k-PMs（153.37 ± 1.00nm）的粒径小于 HA-PMs（223.83 ± 1.84nm），但明显大于 TPGS2k-PMs（约 20nm）。HA/TPGS2k-PMs 的载药效率为 7.10%，低于 HA-PMs（8.31 ± 0.15%），但高于 TPGS2k-PMs（4.38 ± 0.24%）。体外实验表明，在 MCF-7/Adr 细胞中，HA/TPGS2k-PMs 和 TPGS2k-PMs 表现出比 HA-PMs 更高的细胞毒性和逆转多药耐药性作用。然而，HA/TPGS2k-PMs、HA-PMs 和 TPGS2k-PMs 均能显著改善荷瘤 4T1 小鼠的肿瘤组织分布、抗肿瘤效果，并降低 DOX 的副作用，但这三种胶束在体内无差异。因此，PEG 化胶束的 EPR 被动靶向作用和基于 HA 的胶束的 CD44 主动靶向作用在静脉给药时对抗肿瘤药物的传递没有显著差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4f9/6058673/ed3a9b6139d5/IDRD_A_1428385_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4f9/6058673/9f9e4c7d1ad6/IDRD_A_1428385_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4f9/6058673/daa3d5ffe2bb/IDRD_A_1428385_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4f9/6058673/15fd84d4fcc5/IDRD_A_1428385_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4f9/6058673/bb359a06b77d/IDRD_A_1428385_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4f9/6058673/9405f5f73a0f/IDRD_A_1428385_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4f9/6058673/ed3a9b6139d5/IDRD_A_1428385_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4f9/6058673/9f9e4c7d1ad6/IDRD_A_1428385_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4f9/6058673/daa3d5ffe2bb/IDRD_A_1428385_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4f9/6058673/15fd84d4fcc5/IDRD_A_1428385_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4f9/6058673/bb359a06b77d/IDRD_A_1428385_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4f9/6058673/9405f5f73a0f/IDRD_A_1428385_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4f9/6058673/ed3a9b6139d5/IDRD_A_1428385_F0006_C.jpg

相似文献

1
Comparison of hyaluronic acid-based micelles and polyethylene glycol-based micelles on reversal of multidrug resistance and enhanced anticancer efficacy in vitro and in vivo.比较基于透明质酸的胶束和基于聚乙二醇的胶束对逆转多药耐药性和增强体内外抗肿瘤疗效的作用。
Drug Deliv. 2018 Nov;25(1):330-340. doi: 10.1080/10717544.2018.1428385.
2
Enhanced effect of pH-sensitive mixed copolymer micelles for overcoming multidrug resistance of doxorubicin.pH 敏感型混合共聚物胶束增强多柔比星克服多药耐药性的作用。
Biomaterials. 2014 Dec;35(37):9877-9887. doi: 10.1016/j.biomaterials.2014.08.008. Epub 2014 Sep 15.
3
Investigation on vitamin e succinate based intelligent hyaluronic acid micelles for overcoming drug resistance and enhancing anticancer efficacy.基于琥珀酸维生素 E 的智能透明质酸胶束克服耐药性和增强抗癌疗效的研究。
Eur J Pharm Sci. 2019 Dec 1;140:105071. doi: 10.1016/j.ejps.2019.105071. Epub 2019 Sep 13.
4
The effect of dual-functional hyaluronic acid-vitamin E succinate micelles on targeting delivery of doxorubicin.双功能透明质酸-维生素E琥珀酸酯胶束对阿霉素靶向递送的影响
Int J Nanomedicine. 2016 Nov 7;11:5851-5870. doi: 10.2147/IJN.S113882. eCollection 2016.
5
Systematic evaluation of multifunctional paclitaxel-loaded polymeric mixed micelles as a potential anticancer remedy to overcome multidrug resistance.对负载紫杉醇的多功能聚合物混合胶束作为克服多药耐药性的潜在抗癌药物进行系统评价。
Acta Biomater. 2017 Mar 1;50:381-395. doi: 10.1016/j.actbio.2016.12.021. Epub 2016 Dec 9.
6
Co-assembly of doxorubicin and curcumin targeted micelles for synergistic delivery and improving anti-tumor efficacy.阿霉素与姜黄素共组装靶向胶束用于协同递送及提高抗肿瘤疗效
Eur J Pharm Biopharm. 2017 Mar;112:209-223. doi: 10.1016/j.ejpb.2016.11.033. Epub 2016 Nov 29.
7
Micelles of d-α-Tocopheryl Polyethylene Glycol 2000 Succinate (TPGS 2K) for Doxorubicin Delivery with Reversal of Multidrug Resistance.用于阿霉素递送及逆转多药耐药性的琥珀酸聚乙二醇2000 d-α-生育酚（TPGS 2K）胶束
ACS Appl Mater Interfaces. 2015 Aug 19;7(32):18064-75. doi: 10.1021/acsami.5b04995. Epub 2015 Aug 5.
8
Nanomicelles loaded with doxorubicin and curcumin for alleviating multidrug resistance in lung cancer.负载阿霉素和姜黄素的纳米胶束用于缓解肺癌中的多药耐药性。
Int J Nanomedicine. 2016 Nov 3;11:5757-5770. doi: 10.2147/IJN.S118568. eCollection 2016.
9
Star-shape copolymer of lysine-linked di-tocopherol polyethylene glycol 2000 succinate for doxorubicin delivery with reversal of multidrug resistance.赖氨酸连接的生育酚聚乙二醇 2000 琥珀酸二酯星形嵌段共聚物用于阿霉素递送，逆转多药耐药性。
Biomaterials. 2012 Oct;33(28):6877-88. doi: 10.1016/j.biomaterials.2012.06.019. Epub 2012 Jul 6.
10
Multifunctional self-assembled micelles of galactosamine-hyaluronic acid-vitamin E succinate for targeting delivery of norcantharidin to hepatic carcinoma.半乳糖胺-透明质酸-维生素 E 琥珀酸酯的多功能自组装胶束用于靶向递送去甲斑蝥素至肝癌。
Carbohydr Polym. 2018 Oct 1;197:194-203. doi: 10.1016/j.carbpol.2018.05.090. Epub 2018 May 31.

引用本文的文献

1
Polymeric-Micelle-Based Delivery Systems for Nucleic Acids.基于聚合物胶束的核酸递送系统
Pharmaceutics. 2023 Jul 26;15(8):2021. doi: 10.3390/pharmaceutics15082021.
2
Hyaluronic Acid within Self-Assembling Nanoparticles: Endless Possibilities for Targeted Cancer Therapy.自组装纳米颗粒中的透明质酸：靶向癌症治疗的无限可能
Nanomaterials (Basel). 2022 Aug 18;12(16):2851. doi: 10.3390/nano12162851.
3
Glycosaminoglycans: Carriers and Targets for Tailored Anti-Cancer Therapy.糖胺聚糖：定制抗癌疗法的载体与靶点

本文引用的文献

1
Recent Advances in the Application of Vitamin E TPGS for Drug Delivery.维生素 E TPGS 在药物传递中的应用新进展。
Theranostics. 2018 Jan 1;8(2):464-485. doi: 10.7150/thno.22711. eCollection 2018.
2
Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer.芹菜素TPGS脂质体与酪丝缬肽的协同凋亡作用：对肺癌有效治疗的意义
Int J Nanomedicine. 2017 Jul 17;12:5109-5118. doi: 10.2147/IJN.S140096. eCollection 2017.
3
Recent advances in TPGS-based nanoparticles of docetaxel for improved chemotherapy.
Biomolecules. 2021 Mar 8;11(3):395. doi: 10.3390/biom11030395.
4
Micellar Drug Delivery Systems Based on Natural Biopolymers.基于天然生物聚合物的胶束药物递送系统
Polymers (Basel). 2021 Feb 2;13(3):477. doi: 10.3390/polym13030477.
5
Hyaluronic Acid-Coated Nanomedicine for Targeted Cancer Therapy.用于靶向癌症治疗的透明质酸包被纳米药物
Pharmaceutics. 2019 Jun 30;11(7):301. doi: 10.3390/pharmaceutics11070301.
6
Hyaluronic Acid-Decorated Chitosan Nanoparticles for CD44-Targeted Delivery of Everolimus.透明质酸修饰壳聚糖纳米粒用于依维莫司的 CD44 靶向递药。
Int J Mol Sci. 2018 Aug 7;19(8):2310. doi: 10.3390/ijms19082310.
7
PEO-PPO-PEO Tri-Block Copolymers for Gene Delivery Applications in Human Regenerative Medicine-An Overview.PEO-PPO-PEO 三嵌段共聚物在人类再生医学中的基因传递应用概述。
Int J Mol Sci. 2018 Mar 8;19(3):775. doi: 10.3390/ijms19030775.
基于TPGS的多西他赛纳米颗粒在改善化疗方面的最新进展。
Int J Pharm. 2017 Aug 30;529(1-2):506-522. doi: 10.1016/j.ijpharm.2017.07.018. Epub 2017 Jul 12.
4
Enhanced tumor therapy via drug co-delivery and in situ vascular-promoting strategy.通过药物共递药和原位血管促进策略增强肿瘤治疗。
J Control Release. 2017 Jul 28;258:108-120. doi: 10.1016/j.jconrel.2017.05.016. Epub 2017 May 15.
5
Co-assembly of doxorubicin and curcumin targeted micelles for synergistic delivery and improving anti-tumor efficacy.阿霉素与姜黄素共组装靶向胶束用于协同递送及提高抗肿瘤疗效
Eur J Pharm Biopharm. 2017 Mar;112:209-223. doi: 10.1016/j.ejpb.2016.11.033. Epub 2016 Nov 29.
6
The effect of dual-functional hyaluronic acid-vitamin E succinate micelles on targeting delivery of doxorubicin.双功能透明质酸-维生素E琥珀酸酯胶束对阿霉素靶向递送的影响
Int J Nanomedicine. 2016 Nov 7;11:5851-5870. doi: 10.2147/IJN.S113882. eCollection 2016.
7
Tyroservatide-TPGS-paclitaxel liposomes: Tyroservatide as a targeting ligand for improving breast cancer treatment.酪丝缬肽-聚乙二醇化维生素E琥珀酸酯-紫杉醇脂质体：酪丝缬肽作为一种用于改善乳腺癌治疗的靶向配体。
Nanomedicine. 2017 Apr;13(3):1105-1115. doi: 10.1016/j.nano.2016.10.017. Epub 2016 Nov 12.
8
Endogenous stimuli-sensitive multistage polymeric micelleplex anticancer drug delivery system for efficient tumor penetration and cellular internalization.内源性刺激敏感的多阶段聚合物胶束复合物抗癌药物输送系统，用于有效穿透肿瘤和细胞内化。
Adv Healthc Mater. 2015 Oct 28;4(15):2206-19. doi: 10.1002/adhm.201500379. Epub 2015 Sep 8.
9
Hyaluronic Acid-Tocopherol Succinate-Based Self-Assembling Micelles for Targeted Delivery of Rifampicin to Alveolar Macrophages.基于透明质酸-生育酚琥珀酸酯的自组装胶束用于将利福平靶向递送至肺泡巨噬细胞
J Biomed Nanotechnol. 2015 Aug;11(8):1312-29. doi: 10.1166/jbn.2015.2091.
10
Synergistically Improved Anti-tumor Efficacy by Co-delivery Doxorubicin and Curcumin Polymeric Micelles.通过共递送阿霉素和姜黄素聚合物胶束协同提高抗肿瘤疗效
Macromol Biosci. 2015 Sep;15(9):1252-61. doi: 10.1002/mabi.201500043. Epub 2015 May 15.