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Loss of Toll-like receptor 2 results in accelerated leukemogenesis in the mouse model of MDS.

作者信息

Monlish Darlene A, Bhatt Sima T, Duncavage Eric J, Greenberg Zev J, Keller John L, Romine Molly P, Yang Wei, Aplan Peter D, Walter Matthew J, Schuettpelz Laura G

机构信息

Department of Pediatrics.

Department of Pathology, and.

出版信息

Blood. 2018 Mar 1;131(9):1032-1035. doi: 10.1182/blood-2017-08-801944. Epub 2018 Jan 22.

Abstract
摘要

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本文引用的文献

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The Role of Toll-Like Receptors in Hematopoietic Malignancies.
Front Immunol. 2016 Sep 28;7:390. doi: 10.3389/fimmu.2016.00390. eCollection 2016.
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PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia.
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Targeting of the bone marrow microenvironment improves outcome in a murine model of myelodysplastic syndrome.
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Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling.
J Exp Med. 2015 Oct 19;212(11):1967-85. doi: 10.1084/jem.20141898. Epub 2015 Oct 12.
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Toll-like receptor alterations in myelodysplastic syndrome.
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