Richter Yvonne, Lind Pedro G, Maass Philipp
Fachbereich Physik, Universität Osnabrück, Barbarastraße 7, 49076 Osnabrück, Germany.
PLoS One. 2018 Jan 23;13(1):e0190448. doi: 10.1371/journal.pone.0190448. eCollection 2018.
We present an effective method to model empirical action potentials of specific patients in the human atria based on the minimal model of Bueno-Orovio, Cherry and Fenton adapted to atrial electrophysiology. In this model, three ionic are currents introduced, where each of it is governed by a characteristic time scale. By applying a nonlinear optimization procedure, a best combination of the respective time scales is determined, which allows one to reproduce specific action potentials with a given amplitude, width and shape. Possible applications for supporting clinical diagnosis are pointed out.
我们提出了一种有效的方法，基于适用于心房电生理学的布埃诺 - 奥罗维奥、切里和芬顿最小模型，对人类心房中特定患者的经验动作电位进行建模。在该模型中，引入了三种离子电流，每种电流都由一个特征时间尺度控制。通过应用非线性优化程序，确定了各个时间尺度的最佳组合，这使得能够重现具有给定幅度、宽度和形状的特定动作电位。文中指出了该方法在支持临床诊断方面的可能应用。
