Department of Psychiatry and Psychosomatics, I. M. Sechenov First Moscow State Medical University, Mental Health Research Center, 127006 Moscow, Russia.
Acta Derm Venereol. 2018 Oct 10;98(9):848-854. doi: 10.2340/00015555-2888.
We examined the association between the duration of untreated psychosis and outcome for patients with delusional infestation. This multi-centre international study included 211 consecutive patients. Illness severity was evaluated at first presentation and outcome was measured with the Clinical Global Impression scale (CGI) at baseline and follow-up. A regression analysis showed a clear clinical and statistically significant association between shorter duration of untreated psychosis and better outcome at follow-up. Patients with a duration of untreated psychosis of less than one year showed a CGI-S change from 5.37 to 2.07; those with a duration of untreated psychosis of 1-5 years a change from 5.48 to 2.59, and those with a duration of untreated psychosis of >5 years a change from 5.59 to 3.37. This difference of 1.1 CGI points between the groups resembles a clinically relevant difference in patient outcome. Our results suggest that longer duration of untreated psychosis in patients with delusional infestation is associated with significantly less favour-able clinical outcomes.
我们研究了未治疗精神病持续时间与妄想性寄生虫感染患者结局之间的关系。这项多中心国际研究纳入了 211 例连续患者。在首次就诊时评估疾病严重程度，使用临床总体印象量表（CGI）在基线和随访时测量结局。回归分析显示，未治疗精神病持续时间较短与随访时结局更好之间存在明确的临床和统计学显著关联。未治疗精神病持续时间少于 1 年的患者 CGI-S 从 5.37 变为 2.07；未治疗精神病持续时间为 1-5 年的患者从 5.48 变为 2.59，未治疗精神病持续时间超过 5 年的患者从 5.59 变为 3.37。组间 1.1CGI 点的差异类似于患者结局的临床相关差异。我们的结果表明，妄想性寄生虫感染患者的未治疗精神病持续时间较长与临床结局明显较差相关。
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