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A diagnostic conundrum.

作者信息

Keddie Stephen, Jaunmuktane Zane, Brandner Sebastian, Shah Sachit, Maddison Paul, Rees Jeremy H, Hanna Michael G, Lunn Michael P T, Reilly Mary M, Rossor Alexander M, Carr Aisling S

机构信息

Department of Molecular Neuroscience, MRC Centre for Neuromuscular Diseases, National Hospital of Neurology and Neurosurgery, UCL Institute of Neurology, London, UK.

Division of Neuropathology, National Hospital of Neurology and Neurosurgery, UCL Hospitals NHS Foundation Trust, London, UK.

出版信息

Pract Neurol. 2018 Apr;18(2):137-142. doi: 10.1136/practneurol-2017-001801. Epub 2018 Jan 23.

Abstract

We present a 26 year old male with a 6 year history of painful sensory symptoms, weakness and wasting in the legs alongside progressive facial weakness, slurred speech, dysphagia and ophthalmoplegia. There were no neurological symptoms or signs in the upper limbs. Previous medical history included traumatic corneal injury to the left eye in childhood and a cisterna magna choroid plexus papilloma which was removed surgically at age 22. Investigations localised the pathology to the cranial nerve and pre-ganglionic lumbar nerve roots. A dural meningeal biopsy demonstrated grade 1 choroid plexus papilloma, 4 years after presumed curative excision of the original lesion. This presentation with multifocal peripheral nervous system deficits is due to choroid plexus papilloma drop metastases. We summarise the case and discuss the significance of the neurophysiology and imaging findings contributing to diagnosis.

摘要

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本文引用的文献

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Choroid plexus papillomas: advances in molecular biology and understanding of tumorigenesis.
Neuro Oncol. 2013 Mar;15(3):255-67. doi: 10.1093/neuonc/nos289. Epub 2012 Nov 21.
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J Korean Neurosurg Soc. 2007 Dec;42(6):475-7. doi: 10.3340/jkns.2007.42.6.475. Epub 2007 Dec 20.
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Metastatic choroid plexus papilloma: a case report.
J Neurooncol. 2002 Feb;56(3):241-6. doi: 10.1023/a:1015044012574.

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