[吸入一氧化氮治疗新生儿持续性肺动脉高压。]

[TREATMENT WITH INO OF INFANTS WITH PPHN.].

作者信息

Radulova P, Vakrilova L, Slancheva B, Marinov R, Zlatkov V

出版信息

Akush Ginekol (Sofiia). 2016;55(4):58-64.

Abstract

PPHN is a life threatening disease that appears as a result of high pulmonary vascular resistance and persistent right to left shunt across foramen ovale and ductus arteriosus. The treatment of PPHN is complex and often ineffective. iNO is important part of the pathogenetic treatment of the disease. We present six infants with PPHN treated with iNO. The clinical effect of the drug was quick and the hemodynamics stabilized. All infants survived without side effects and with better neurodevelopment outcome.

摘要

新生儿持续性肺动脉高压是一种危及生命的疾病，其出现是由于肺血管阻力升高以及卵圆孔和动脉导管处持续的右向左分流所致。新生儿持续性肺动脉高压的治疗复杂且常常无效。吸入一氧化氮是该疾病发病机制治疗的重要组成部分。我们报告了6例接受吸入一氧化氮治疗的新生儿持续性肺动脉高压患儿。该药临床效果迅速，血流动力学稳定。所有患儿均存活，无副作用，且神经发育结局较好。