持续的挑战：N-杂环卡宾催化γ-丁内酯合成。
A continuing challenge: N-heterocyclic carbene-catalyzed syntheses of γ-butyrolactones.
机构信息
Department of Chemistry, Department of Pharmacology, Center for Molecular Innovation and Drug Discovery, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.
出版信息
Chem Soc Rev. 2018 Mar 5;47(5):1773-1782. doi: 10.1039/c7cs00386b.
Catalytic, stereoselective N-heterocyclic carbene-catalyzed reactions facilitate efficient construction of many different heterocyclic compounds, such as the enantioenriched 5-membered (γ) lactones highlighted in this tutorial review. Herein, various strategies to enable formal [3+2] type annulations between electrophilic carbonyl equivalents and homoenolate nucleophiles for the synthesis of γ-lactones are summarized.
催化、立体选择性的 N-杂环卡宾催化反应促进了许多不同杂环化合物的有效构建，如本综述中突出显示的对映体富集的 5 元（γ）内酯。本文总结了各种策略，可用于通过亲电羰基等价物和偕同烯醇亲核试剂之间的形式[3+2]型环加成反应来合成γ-内酯。
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