Williams Bethany D, Sisson Susan B, Ardern Chris A, DuBose Katrina D, Johnson Tammie M, Richardson M Ryan, Churilla James R
1 Department of Clinical & Applied Movement Sciences, Brooks College of Health, University of North Florida , Jacksonville, Florida.
2 Department of Nutrition Sciences, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma.
Metab Syndr Relat Disord. 2018 Mar;16(2):97-103. doi: 10.1089/met.2017.0072. Epub 2018 Jan 29.
While studies to date have shown that children and adolescents who meet the current physical activity (PA) recommendations and maintain a healthy body weight demonstrate significantly lower cardiometabolic risk, there are some studies that suggest that the relationship between PA and metabolic risk may be mediated by adiposity. The aim of the present study was to examine variation in clustered metabolic risk (cMetS) in adolescents classified as not overweight/active (NOA), not overweight/not active (NONA), overweight/active (OA), and overweight/not active (ONA).
The sample included adolescent participants (n = 875; 12-17 years) of the 2007-2012 National Health and Nutrition Examination Survey (NHANES). The cMetS score included triglycerides, high-density lipoprotein cholesterol, fasting plasma glucose, and mean arterial pressure. Age- and sex-specific body mass index (BMI) percentiles were utilized; overweight was defined as BMI percentile ≥85th. Activity data included self-reported frequency of moderate-to-vigorous PA. Adolescents reporting ≥60 min/day of PA were considered "active." General linear models, adjusted for age, sex, and race-ethnicity, were used. A 6-year fasting sample weight was applied to the analyses to ensure representativeness of the data.
The cMetS scores were significantly (P < 0.05) higher in OA and ONA adolescents compared to NOA (β = 1.08 and β = 1.57, respectively). In ONA males, cMetS was significantly (P < 0.01) higher compared to NOA males. In OA and ONA females, cMetS scores were significantly higher compared to the referent group (P < 0.01 for both).
The cMetS scores were increased in overweight adolescents compared to those who were not overweight, regardless of their reported activity level.
尽管迄今为止的研究表明，达到当前身体活动（PA）建议并保持健康体重的儿童和青少年表现出显著更低的心脏代谢风险，但也有一些研究表明，PA与代谢风险之间的关系可能由肥胖介导。本研究的目的是检查分类为非超重/活跃（NOA）、非超重/不活跃（NONA）、超重/活跃（OA）和超重/不活跃（ONA）的青少年中聚集代谢风险（cMetS）的差异。
样本包括2007 - 2012年国家健康和营养检查调查（NHANES）的青少年参与者（n = 875；12 - 17岁）。cMetS评分包括甘油三酯、高密度脂蛋白胆固醇、空腹血糖和平均动脉压。使用了按年龄和性别划分的体重指数（BMI）百分位数；超重定义为BMI百分位数≥85。活动数据包括自我报告的中度至剧烈PA频率。报告PA≥60分钟/天的青少年被视为“活跃”。使用了针对年龄、性别和种族进行调整的一般线性模型。将6年的空腹样本权重应用于分析以确保数据的代表性。
与NOA青少年相比，OA和ONA青少年的cMetS评分显著更高（P < 0.05）（β分别为1.08和1.57）。在ONA男性中，与NOA男性相比，cMetS显著更高（P < 0.01）。在OA和ONA女性中，cMetS评分与参照组相比显著更高（两者均P < 0.01）。
与非超重青少年相比，超重青少年的cMetS评分升高，无论其报告的活动水平如何。
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