Ng Lay Guat
Department of Urology, Singapore General Hospital, Singapore.
Asian J Urol. 2018 Jan;5(1):33-36. doi: 10.1016/j.ajur.2017.11.003. Epub 2017 Nov 22.
Benign prostatic hyperplasia (BPH) is a clinical condition where lower urinary tract symptoms are caused by both a physically obstructing prostate as well as tight smooth muscles around the bladder outlet. Treatment of this condition with botulinum toxin has been used since 2003, but this interest has somewhat died down after two large randomized controlled trials (RCTs) showing equivalence of results between their treatment and placebo arms. However, with review of animal studies and unexplained exaggerated effect of the placebo arms of the two RCTs, together with recent data of sustained benefits after 18 months of treatment, the place of botulinum toxin in the BPH field is probably still present.
良性前列腺增生（BPH）是一种临床病症，下尿路症状由物理性阻塞前列腺以及膀胱出口周围紧绷的平滑肌共同引起。自2003年以来，肉毒杆菌毒素一直被用于治疗这种病症，但在两项大型随机对照试验（RCT）表明其治疗组与安慰剂组结果相当之后，这种兴趣有所减弱。然而，通过回顾动物研究以及两项RCT中安慰剂组无法解释的夸大效果，再加上近期治疗18个月后持续获益的数据，肉毒杆菌毒素在BPH领域可能仍有一席之地。
