Liccardi G, Calzetta L, Salzillo A, Apicella G, Piccolo A, Di Maro E, Rogliani P
Department of Pulmonology, Haematology and Oncology, Division of Pulmonology and Allergology, High Speciality A. Cardarelli Hospital, Naples, Italy. Postgraduate School of Respiratory Medicine, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Postgraduate School of Respiratory Medicine, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy. Department of Experimental Medicine, Unit of Respiratory Medicine, University of Rome Tor Vergata, Rome, Italy.
Eur Ann Allergy Clin Immunol. 2018 Nov;50(6):283-285. doi: 10.23822/EurAnnACI.1764-1489.41. Epub 2017 Nov 30.
Recent studies have shown the increasing relevance of allergic sensitization to Can f 5 (a prostatic kallikrein), which is an androgen-regulated protein expressed in the prostate and detectable only in male dogs. Can f 5 can be a prevalent or exclusive sensitizing agent in a considerable percentage of dog-allergic patients. Its specific allergenic characteristics are able to induce possible negative as well as positive clinical effects in individuals sensitized to dogs. In the present article we pointed out the possible pros or cons of sensitization to this allergen in real life. Further studies should be carried out to correctly assess some peculiar characteristics of Can f 5, in order to support the most of positive aspects and remedy at best the negative effects.
最近的研究表明，对犬小孢子菌5（一种前列腺激肽释放酶）的过敏致敏作用越来越受到关注，它是一种受雄激素调节的蛋白质，在前列腺中表达，仅在雄性犬中可检测到。在相当比例的对犬过敏的患者中，犬小孢子菌5可能是一种普遍存在或唯一的致敏原。其特定的致敏特性能够在对犬过敏的个体中引发可能的负面和正面临床效应。在本文中，我们指出了在现实生活中对这种过敏原致敏可能产生的利弊。应进一步开展研究，以正确评估犬小孢子菌5的一些特殊特性，以便最大限度地发挥其积极作用，并尽可能弥补其负面影响。
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