Schulte-Sasse U, Eberlein H J
Anaesthesist. 1986 Jan;35(1):1-9.
New publications on malignant hyperthermia (MH), with direct clinical importance, are reported. Since even in the recent past patients have died from MH in spite of therapy with dantrolene, the effectiveness of dantrolene is discussed in particular. Atypical clinical pictures of MH are presented. Special psychiatric syndromes (malignant neuroleptic syndrome and acute febrile catatonia), rhabdomyolysis with myoglobinuria following strenuous exercise or exposure to heat are mentioned, as these disorders appear to be related to MH, in that they are hypermetabolic syndromes implying a muscle membrane dysfunction. The role of slow calcium channel blockers and 5-hydroxytryptamine antagonists as prophylactic or therapeutic agents in MH is discussed. A schedule describing how to diagnose, treat and prevent MH, considering recent advances, is presented.
报道了关于恶性高热(MH)的具有直接临床重要性的新出版物。由于即使在最近,尽管使用丹曲林进行治疗,仍有患者死于MH,因此特别讨论了丹曲林的有效性。文中呈现了MH的非典型临床表现。提到了特殊的精神综合征(恶性抗精神病药物综合征和急性发热性紧张症)、剧烈运动或受热后伴有肌红蛋白尿的横纹肌溶解症,因为这些疾病似乎与MH有关,它们是暗示肌肉膜功能障碍的高代谢综合征。讨论了慢钙通道阻滞剂和5-羟色胺拮抗剂在MH中作为预防或治疗药物的作用。根据最新进展,给出了一份关于如何诊断、治疗和预防MH的方案。