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尼泊尔三级医院中与脐带结扎时机相关的因素。

Factors associated with timing of umbilical cord clamping in tertiary hospital of Nepal.

作者信息

Nelin Viktoria, Kc Ashish, Andersson Ola, Rana Nisha, Målqvist Mats

机构信息

International Maternal and Child Health, Department of Women's and Children's Health, Uppsala University, University Hospital, 751 85, Uppsala, Sweden.

United Nation's Children's Fund (UNICEF), Nepal Country Office, UN House, Pulchowk, Kathmandu, Nepal.

出版信息

BMC Res Notes. 2018 Jan 31;11(1):89. doi: 10.1186/s13104-018-3198-8.

Abstract

OBJECTIVE

Delayed umbilical cord clamping (DCC) (≥ 60 s) is recognized to improve iron status and neurodevelopment compared to early umbilical cord clamping. The aim of this study is to identify current umbilical cord clamping practice and factors determining the timing of clamping in a low-resource setting where prevalence of anemia in infants is high.

RESULTS

A cross-sectional study design including 128 observations of clinical practice in a tertiary-level maternity hospital in Kathmandu, Nepal. Overall 48% of infants received DCC. The mean and median cord clamping times were 61 ± 33 and 57 (38-79) s, respectively. Univariate analysis showed that infants born during the night shift were five times more likely to receive DCC (OR 5.6, 95% CI 1.4-38.0). Additionally, infants born after an obstetric complication were 2.5 times more likely to receive DCC (OR 2.5, 95% CI 1.2-5.3), and babies requiring ventilation had a 65% lower likelihood of receiving DCC (OR 0.35, 95% CI 0.13-0.88). Despite the existence of standard protocols for cord clamping and its proven benefit, the lack of uniformity in the timing of cord clamping reveals poor translation of clinical guidelines into clinical practice. Clinical trial registration ISRCTN97846009.

摘要

目的

与早期脐带结扎相比,延迟脐带结扎(DCC)(≥60秒)被认为可改善铁状态和神经发育。本研究的目的是确定在婴儿贫血患病率高的资源匮乏地区当前的脐带结扎做法以及决定结扎时间的因素。

结果

采用横断面研究设计,对尼泊尔加德满都一家三级妇产医院的128例临床实践观察进行了研究。总体而言,48%的婴儿接受了延迟脐带结扎。脐带结扎的平均时间和中位数时间分别为61±33秒和57(38 - 79)秒。单因素分析显示,夜班出生的婴儿接受延迟脐带结扎的可能性是其他婴儿的五倍(比值比5.6,95%置信区间1.4 - 38.0)。此外,产科并发症后出生的婴儿接受延迟脐带结扎的可能性是其他婴儿的2.5倍(比值比2.5,95%置信区间1.2 - 5.3),而需要通气的婴儿接受延迟脐带结扎的可能性降低65%(比值比0.35,95%置信区间0.13 - 0.88)。尽管存在脐带结扎的标准方案及其已证实的益处,但脐带结扎时间缺乏一致性表明临床指南在临床实践中的转化效果不佳。临床试验注册号:ISRCTN97846009。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cba7/5793403/254eabb05656/13104_2018_3198_Fig1_HTML.jpg

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