Khay Khadija, Arous Salim, Bentaoune Tarik, Drighil Abdenasser, Habbal Rachida
Department of Cardiology, Ibn Rushd University Hospital, Casablanca, Morocco.
J Med Case Rep. 2018 Jan 31;12(1):23. doi: 10.1186/s13256-018-1574-6.
Carcinoid heart disease is a frequent complication of carcinoid syndrome. It is related to the release by the carcinoid tumor and/or its metastases of bioactive substances such as serotonin. It is characterized by right-sided valvular involvement and can lead to right-sided heart failure. It is a prognostic factor of carcinoid syndrome.
We report the case of a 53-year-old African woman with an endocrine tumor of her small intestine complicated by carcinoid heart disease, revealed by right-sided heart failure. The diagnosis was confirmed by transthoracic echocardiography, which showed a severe tricuspid regurgitation with a patent foramen ovale, and by increased serum chromogranin A and urinary 5-hydroxyindoleacetic acid. Initially she was treated with medical therapy (furosemide and injection of somatostatin). Afterwards she was proposed for surgery. The evolution of her treatment was good.
Carcinoid syndrome is complicated in 60% of the cases of a heart disease, and is responsible for an important morbidity and mortality. The prognosis of patients with carcinoid heart disease has improved in recent years through somatostatin analogues and the cardiac surgery.
类癌性心脏病是类癌综合征常见的并发症。它与类癌肿瘤和/或其转移灶释放生物活性物质如血清素有关。其特征为右侧瓣膜受累，可导致右心衰竭。它是类癌综合征的一个预后因素。
我们报告了一例53岁非洲女性，患有小肠内分泌肿瘤并并发类癌性心脏病，以右心衰竭为首发表现。经胸超声心动图显示严重三尖瓣反流伴卵圆孔未闭，血清嗜铬粒蛋白A和尿5-羟吲哚乙酸升高，确诊为此病。最初她接受药物治疗（呋塞米和注射生长抑素）。之后建议她进行手术。她的治疗进展良好。
60%的类癌综合征病例并发心脏病，且导致严重的发病率和死亡率。近年来，通过生长抑素类似物和心脏手术，类癌性心脏病患者的预后有所改善。
Zotero 插件
