磷酸二酯酶9（PDE9）调节牛气管平滑肌舒张。
Phosphodiesterase 9 (PDE9) regulates bovine tracheal smooth muscle relaxation.
作者信息
Tajima Tsuyoshi, Shinoda Tamami, Urakawa Norimoto, Shimizu Kazumasa, Kaneda Takeharu
机构信息
Laboratory of Veterinary Pharmacology, Nippon Veterinary and Life Science University, 1-7-1 Kyounan-cho, Musashino-shi, Tokyo 180-8602, Japan.
出版信息
J Vet Med Sci. 2018 Mar 24;80(3):499-502. doi: 10.1292/jvms.18-0011. Epub 2018 Jan 30.
The present study was designed to clarify phosphodiesterase 9 (PDE9) expression in bovine tracheal smooth muscle tissue, and to elucidate that PDE9 may contribute to the regulation of airway relaxation. PDE9 mRNA expression was detected in bovine tracheal smooth muscle. Sodium nitroprusside (an NO donor) and BAY 73-6691 (a selective PDE9 inhibitor) reduced high K- and carbachol-induced contraction. BAY 73-6691 relaxed tracheal tissue on the same level with vardenafil (a selective PDE5 inhibitor). These results support our hypothesis that PDE9 plays functional role in the tracheal smooth muscle relaxation. PDE9 inhibitors are expected to be a novel target of the add-on treatment of airway hyperresponsiveness.
本研究旨在阐明磷酸二酯酶9（PDE9）在牛气管平滑肌组织中的表达，并阐明PDE9可能有助于气道舒张的调节。在牛气管平滑肌中检测到了PDE9 mRNA的表达。硝普钠（一种NO供体）和BAY 73-6691（一种选择性PDE9抑制剂）可降低高钾和卡巴胆碱诱导的收缩。BAY 73-6691使气管组织舒张的程度与伐地那非（一种选择性PDE5抑制剂）相同。这些结果支持了我们的假设，即PDE9在气管平滑肌舒张中发挥功能性作用。PDE9抑制剂有望成为气道高反应性附加治疗的新靶点。
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