经肌内注射向椎旁间隙扩散的竖脊肌阻滞:一项志愿者研究。
Spread of Quadratus Lumborum Block to the Paravertebral Space Via Intramuscular Injection: A Volunteer Study.
出版信息
Reg Anesth Pain Med. 2018 May;43(4):372-377. doi: 10.1097/AAP.0000000000000735.
BACKGROUND AND OBJECTIVES
Several types of quadratus lumborum block (QLB) are used for postoperative analgesia and are believed to be effective against both somatic and visceral pain via a local anesthetic (LA) effect in the paravertebral space (PVS). However, it remains unclear whether all QLB techniques result in LA spread into the PVS. We hypothesized that LA administered via intramuscular QLB would spread into the paravertebral space and investigated the spread and sensory block area of LA in intramuscular QLB.
METHODS
This volunteer study included 5 healthy men and 1 woman, with no previous medical history. Intramuscular QLB and lateral transversus abdominis plane block were performed under real-time ultrasound guidance for comparison of sensory deprivation range. Two days later, the same procedure was performed on the contralateral side of the body. The spread of LA via intramuscular QLB spread to the PVS was assessed 1 hour after the first injections using magnetic resonance imaging. Sensory perception was also evaluated by the pinprick test at 90 minutes after injection.
RESULTS
In total, we performed 11 intramuscular QLBs and 11 lateral transversus abdominis plane blocks. Magnetic resonance imaging showed that LA did not spread into the PVS after ultrasound-guided intramuscular QLB. The analgesic area corresponded to the side of the body that was ipsilateral to the block.
CONCLUSIONS
Ultrasound-guided intramuscular QLBs are not clinically useful for procedures requiring LA spread into the PVS but do result in an ipsilateral analgesic effect in healthy volunteers.
CLINICAL TRIAL REGISTRATION
This study was registered at University Hospital Medical Information Network Clinical Trials Registry, UMIN 000019149.
背景与目的
几种类型的竖脊肌阻滞(QLB)用于术后镇痛,据信通过局部麻醉剂(LA)在椎旁间隙(PVS)中的作用,对躯体和内脏疼痛均有效。然而,目前尚不清楚所有 QLB 技术是否都能使 LA 扩散到 PVS 中。我们假设通过肌内 QLB 给予的 LA 会扩散到椎旁间隙,并研究肌内 QLB 中 LA 的扩散和感觉阻滞区域。
方法
本志愿者研究纳入了 5 名健康男性和 1 名女性,无既往病史。在实时超声引导下进行肌内 QLB 和外侧横突腹平面阻滞,以比较感觉缺失范围。两天后,在身体的对侧进行相同的操作。首次注射后 1 小时,使用磁共振成像评估 LA 通过肌内 QLB 扩散到 PVS 的情况。注射后 90 分钟,通过针刺试验评估感觉感知。
结果
总共进行了 11 次肌内 QLB 和 11 次外侧横突腹平面阻滞。磁共振成像显示,超声引导下肌内 QLB 后,LA 未扩散到 PVS。镇痛区域与阻滞同侧的身体侧面相对应。
结论
超声引导下肌内 QLB 对于需要 LA 扩散到 PVS 的操作并不具有临床实用性,但在健康志愿者中确实会产生同侧的镇痛效果。
临床试验注册
本研究在大学医院医疗信息网络临床试验注册处(UMIN 000019149)进行了注册。