Li Xiaomiao, Fu Xiaodong, Gao Yingjian, Li Hao, Wang Weili, Shen Yi
Department of Orthopedics, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China.
Exp Ther Med. 2018 Jan;15(1):885-889. doi: 10.3892/etm.2017.5462. Epub 2017 Nov 8.
The purpose of this study was to determine the expression and impact of tissue inhibitor of metalloproteinases-1 (TIMP-1) and B-cell lymphoma-2 (Bcl-2) in knee osteoarthritis (KOA). We collected synovial fluids from the knee joint of 70 KOA patients and 30 controls. The expression levels of TIMP-1 and Bcl-2 were significantly higher in KOA patients than those in the control group (P<0.01). We also found positive correlation between the severity of KOA and the expression level of TIMP-1 (r=0.8027, P<0.05) and and Bcl-2 (r=0.5336, P<0.05). However, we found no correlation between the expression levels of TIMP-1 and Bcl-2 in the synovial membranes of KOA patients (P>0.05). Both TIMP-1 and Bcl-2 are expressed at high levels in the synovial membrane with KOA, and are closely related to the occurrence and development of KOA. Thus, detection of TIMP-1 and Bcl-2 in KOA patients can be helpful in diagnosing the state of KOA.
本研究的目的是确定金属蛋白酶组织抑制剂-1（TIMP-1）和B细胞淋巴瘤-2（Bcl-2）在膝关节骨关节炎（KOA）中的表达及影响。我们收集了70例KOA患者和30例对照者膝关节的滑液。KOA患者中TIMP-1和Bcl-2的表达水平显著高于对照组（P<0.01）。我们还发现KOA的严重程度与TIMP-1（r=0.8027，P<0.05）和Bcl-2（r=0.5336，P<0.05）的表达水平呈正相关。然而，我们发现KOA患者滑膜中TIMP-1和Bcl-2的表达水平之间无相关性（P>0.05）。TIMP-1和Bcl-2在KOA滑膜中均高表达，且与KOA的发生发展密切相关。因此，检测KOA患者的TIMP-1和Bcl-2有助于诊断KOA的状态。
Zotero 插件