Inchauspe S, Echandi L V, Dodds E M
Consultores Oftalmológicos, Buenos Aires, Argentina.
Consultores Oftalmológicos, Hospital Juan A. Fernandez, Buenos Aires, Argentina.
Arch Soc Esp Oftalmol (Engl Ed). 2018 May;93(5):220-224. doi: 10.1016/j.oftal.2017.11.012.
To demonstrate the production of the local toxocara antibodies in the vitreous of patients with negative serology.
Retrospective review of the medical records of patients seen in a Tertiary Referral Hospital, and at an Eye Institute, with an ocular diagnosis of toxocariasis who had a negative serology and positive titres in the vitreous.
After reviewing the medical records of 40 patients with a diagnosis of ocular toxocariasis, a total of six cases (15%) were found with a negative serology and a positive vitreous titre for toxocara antibody, both of them performed using an ELISA procedure. The mean age was 18 years, there were no differences observed between males and females. A peripheral granuloma was the most common clinic finding, and all patients underwent vitrectomy either to remove epiretinal membranes or to repair retinal detachments.
A negative serology does not rule out a diagnosis of ocular toxocariasis. Vitreous samples may be necessary to confirm a clinical diagnosis.
证实血清学检查阴性的患者玻璃体内存在局部弓蛔虫抗体。
回顾性分析一家三级转诊医院和一家眼科研究所中被诊断为弓蛔虫病且血清学检查阴性但玻璃体内抗体滴度呈阳性的患者的病历。
在回顾了40例诊断为眼弓蛔虫病的患者病历后，共发现6例（15%）血清学检查阴性但玻璃体内弓蛔虫抗体滴度呈阳性，二者均采用酶联免疫吸附测定法检测。平均年龄为18岁，男女之间未观察到差异。周边肉芽肿是最常见的临床发现，所有患者均接受了玻璃体切除术，要么是为了清除视网膜前膜，要么是为了修复视网膜脱离。
血清学检查阴性不能排除眼弓蛔虫病的诊断。可能需要玻璃体样本以确诊临床诊断。
