Department of Psychiatry, La Fe University and Polytechnic Hospital, Valencia, Spain.
Neonatal Research Unit, La Fe Health Research Institute, Valencia, Spain.
J Affect Disord. 2018 Apr 1;230:101-107. doi: 10.1016/j.jad.2018.01.007. Epub 2018 Jan 31.
Bipolar disorder (BD) is a disabling illness that is associated with low quality of life (QoL). This low QoL goes further than mood episodes, which suggests that stable traits, such as affective temperaments, can cause functional impairment.
Our study analyses the impact of affective temperaments on the Physical Component Summary (PCS) and Mental Component Summary (MCS) of QoL in euthymic BD patients.
A multicentre study was conducted in 180 euthymic BD patients and 95 healthy controls. Firstly, statistical analyses were performed to compare QoL and affective temperaments between the two groups. Secondly, Adaptive Lasso Analysis was carried out to identify the potential confounding variables and select the affective temperaments as potential predictors on the PCS and MCS of QoL in BD patients, as well as the control group.
QoL scores in terms of PCS and MCS in BD patients were significantly lower than in healthy individuals. Whereas anxious temperament, anxiety disorder comorbidity, and age were the best predictors of PCS impairment in BD patients, anxious temperament, subclinical depressive symptoms, and age were the best predictors of MCS impairment.
Further longitudinal studies with unaffected high-risk relatives are needed to examine the potential interaction between affective temperament and psychopathology.
Anxious temperament has an impact on QoL in BD in terms of both the physical component and the mental component. Systematic screening of temperament in BD would give clinicians better knowledge of QoL predictors. Further research should allow more individualized treatment of BD patients based on temperamental factors.
双相情感障碍（BD）是一种使人丧失能力的疾病，其生活质量（QoL）较低。这种低 QoL 不仅仅是情绪发作，这表明稳定的特征，如情感气质，可能导致功能障碍。
我们的研究分析了情感气质对双相情感障碍患者情绪稳定期生活质量的生理成分综合评分（PCS）和心理成分综合评分（MCS）的影响。
在 180 名情绪稳定的双相情感障碍患者和 95 名健康对照者中进行了一项多中心研究。首先，进行了统计分析，以比较两组的 QoL 和情感气质。其次，进行了自适应套索分析，以确定潜在的混杂变量，并选择情感气质作为双相情感障碍患者和对照组 PCS 和 MCS 潜在的预测因素。
双相情感障碍患者的 PCS 和 MCS 生活质量评分明显低于健康个体。然而，焦虑气质、焦虑障碍共病和年龄是双相情感障碍患者 PCS 受损的最佳预测因素，而焦虑气质、亚临床抑郁症状和年龄是 MCS 受损的最佳预测因素。
需要进一步对未受影响的高危亲属进行纵向研究，以检查情感气质与精神病理学之间的潜在相互作用。
焦虑气质对双相情感障碍患者的生活质量有影响，无论是在生理成分还是心理成分方面。在双相情感障碍患者中进行气质系统筛查，将使临床医生更好地了解 QoL 的预测因素。进一步的研究应该允许根据气质因素对双相情感障碍患者进行更个体化的治疗。
