伏隔核 - 苍白球切断术后动机的反常增强。
Paradoxical accentuation of motivation following accumbens-pallidum disconnection.
作者信息
Chang Stephen E, Todd Travis P, Smith Kyle S
机构信息
Dartmouth College, Department of Psychological and Brain Sciences, 6207 Moore Hall, Hanover, NH 03755, United States.
Dartmouth College, Department of Psychological and Brain Sciences, 6207 Moore Hall, Hanover, NH 03755, United States.
出版信息
Neurobiol Learn Mem. 2018 Mar;149:39-45. doi: 10.1016/j.nlm.2018.02.001. Epub 2018 Feb 3.
Abstract
The nucleus accumbens (NAc) and ventral pallidum (VP) are reciprocally connected, and activity within this circuit is thought to promote reward learning. Inconsistent with this notion, we find that disconnecting NAc medial shell and VP greatly enhances the attribution of value to a cue that is paired with reward. This result suggests that medial NAc shell and VP are both needed for attributing value to cues yet can also oppose one-another's functional contribution.
摘要
伏隔核（NAc）与腹侧苍白球（VP）相互连接，并且该神经回路中的活动被认为可促进奖赏学习。与这一观点不一致的是，我们发现切断伏隔核内侧壳与腹侧苍白球之间的联系会极大地增强对与奖赏配对的线索的价值归因。这一结果表明，伏隔核内侧壳和腹侧苍白球对于线索的价值归因都是必需的，但它们也可能相互拮抗彼此的功能作用。
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