Kiszkaą Joanna, Karczmarek-Borowska Bożenna
Subcarpatia Cancer Center in Rzeszow, Poland.
Department of Oncology, Faculty of Medicine, University of Rzeszow, Poland.
Contemp Oncol (Pozn). 2017;21(4):274-278. doi: 10.5114/wo.2017.72153. Epub 2017 Dec 30.
The liver is an organ that, due to vascularisation and functions, is prone to metastases. Most liver metastases are observed in cases of gastrointestinal cancers in: stomach, colon, gallbladder, and bile ducts. Metastatic lesions are also observed in lung, breast, thyroid, kidney, and pancreatic cancer. One of the best known and most effective ways of liver lesion treatment is Metastasectomy. Unfortunately, lesions are frequently inoperable. Apart from chemotherapy, it is possible to apply local treatment such as TACE (trans-arterial chemoembolisation), RFA (Radio Frequency Ablation), and SBRT (Stereotactic Body Radiation Therapy). One of the newest methods of inoperable lesion treatment is radioembolisation (SIRT). Intravascular administration of microspheres containing radioisotope 90Y allows delivery of a higher dose of radiation directly to the tumour than traditional radiation with an external beam, while maintaining a small dose to healthy liver methods. Conducted clinical studies confirm the efficacy and safety of SIRT. It is an interesting alternative to other ways of treatment.
肝脏是一个因其血管分布和功能而易于发生转移的器官。大多数肝转移在胃肠道癌症病例中可见，如胃癌、结肠癌、胆囊癌和胆管癌。在肺癌、乳腺癌、甲状腺癌、肾癌和胰腺癌中也可观察到转移病灶。肝转移灶治疗最著名且最有效的方法之一是肝转移瘤切除术。不幸的是，病灶常常无法手术切除。除化疗外，还可以应用局部治疗，如经动脉化疗栓塞术（TACE）、射频消融术（RFA）和立体定向体部放射治疗（SBRT）。不可切除病灶治疗的最新方法之一是放射性栓塞（SIRT）。血管内注射含有放射性同位素钇-90的微球，与传统外照射放疗相比，可将更高剂量的辐射直接传递至肿瘤，同时对健康肝脏的剂量保持较小。已开展的临床研究证实了SIRT的有效性和安全性。它是其他治疗方式的一个有趣替代方案。
