胚胎期皮肤发育与修复。
Embryonic skin development and repair.
作者信息
Hu Michael S, Borrelli Mimi R, Hong Wan Xing, Malhotra Samir, Cheung Alexander T M, Ransom Ryan C, Rennert Robert C, Morrison Shane D, Lorenz H Peter, Longaker Michael T
机构信息
a Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery , Division of Plastic Surgery, Stanford University School of Medicine , Stanford , California.
b Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine , Stanford , California.
出版信息
Organogenesis. 2018 Jan 2;14(1):46-63. doi: 10.1080/15476278.2017.1421882. Epub 2018 Feb 15.
Abstract
Fetal cutaneous wounds have the unique ability to completely regenerate wounded skin and heal without scarring. However, adult cutaneous wounds heal via a fibroproliferative response which results in the formation of a scar. Understanding the mechanism(s) of scarless wound healing leads to enormous clinical potential in facilitating an environment conducive to scarless healing in adult cutaneous wounds. This article reviews the embryonic development of the skin and outlines the structural and functional differences in adult and fetal wound healing phenotypes. A review of current developments made towards applying this clinical knowledge to promote scarless healing in adult wounds is addressed.
摘要
胎儿皮肤伤口具有独特的能力，能够使受伤皮肤完全再生且愈合后不留疤痕。然而，成人皮肤伤口通过纤维增生性反应愈合，会形成疤痕。了解无疤痕伤口愈合的机制在营造有利于成人皮肤伤口无疤痕愈合的环境方面具有巨大的临床潜力。本文回顾了皮肤的胚胎发育过程，并概述了成人和胎儿伤口愈合表型在结构和功能上的差异。还探讨了将这一临床知识应用于促进成人伤口无疤痕愈合的当前进展。
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